肝硬化腹水并发自发性细菌性腹膜炎临床疗效观察

Observation on clinical treatment effect of cirrhosis with ascites and spontaneous bacterial peritonitis

目的探讨乙型肝炎肝硬化并发自发性细菌性腹膜炎(SBP)的临床疗效。方法探究主体为234例肝硬化者,依照治疗药物的不同随机分两组。对照组使用的药物是左氧氟沙星,治疗组加用培菲康。结果两组SBP的治疗结果差距较大,观察组的腹水治疗以及肝功能改善明显较好。观察组患者的平均腹水消失时间为(4.33±0.34)d,而对照组是(10.32±0.58)d,t=96.371,P<0.01,差异存在统计学意义。观察组治疗后的ALT为(352.35±10.45)U/L,而对照组则是(249.57±10.47)U/L,P<0.01,差异存在统计学意义。其余肝功能指标TBIL(t=46.986,P<0.01)以及Aib(t=29.107,P<0.01)均存在较大的差异,P<0.01,差异存在统计学意义。结论肝硬化合并SBP者加用培菲康能够帮助加快治愈,有较好的治疗效果。

Objective To investigate the clinical treatment of hepatitis B liver cirrhosis spontaneous bacterial peritonitis （SBP）. Methods The subject of exploration for 234 cases of liver cirrhosis, according to different medicine treatment were randomly divided into two groups. The control group used levofloxacin medicine, treatment group was added with bifico. Results the two groups of treatment outcome of SBP gap, ascites and liver function improved in treatment group was significantly better. Observed mean ascites patients disappeared time was （4.33±0.34）d, while the control group was （10.32±0.58）d, t=96.371, P〈0.01, there were statistical significance in the difference. The observation group after treatment ALT （352.35±10.45） U/L, and the control group was （249.57±10.47） U/L, P〈0.01, there were statistical significance in the difference. The indexes of liver function TBIL （t=46.986, P〈0.01） and AIB （t=29.107, P〈0.01） there were large differences. P〈0.01, there were statistical significance in the difference. Conclusion Liver cirrhosis complicated by SBP combined with Bifico can help accelerate the cure, have a better therapeutic effect.