可溶性髓系细胞触发受体-1表达水平与胸腔积液性质的相关性

Relationship between level of soluble triggering receptor expressed on myeloid cells-1 and pleural effusion

目的:探讨可溶性髓系细胞触发受体-1(sTREM-1)表达水平与胸腔积液性质的相关性。方法:选择胸腔积液患者84例为研究对象(分为4组:结核性胸水24例;细菌性胸水22例;肿瘤性胸水16例;漏出液22例)。用酶联免疫吸附法(ELISA)分别检测患者胸水和血清中sTREM-1的表达水平,并分析比较。结果:4组患者胸水中,细菌性胸水组sTREM-1表达增高最显著,肿瘤性胸水组次之,漏出液胸水sTREM-1表达最低。4组患者血清中,细菌性胸水组sTREM-1的表达增高也最为显著,其他3组间差异无统计学意义。结论:sTREM-1表达水平对细菌性胸水、结核性胸水、肿瘤性胸水以及漏出液的鉴别诊断有较好价值,特别是对以胸膜细菌感染时胸水的诊断有较重要意义。

Objective：To explore the relationship between the level of soluble triggering receptor expressed on myeloid cells-1 （sTREM-1） and pleural effusion. Method： A total of 84 patients with pleural effusion were selected as subjects who had been divided into four groups： tuberculosis pleural effusion 24 cases; bacterial pleural effusion 22 cases; tumorous pleural effusion 16 cases; non inflammatory pleural effusion 22 cases, sTREM-1 was measured in pleural effusion and serum of total 84 patients by ELISA. Result： The expression of serum and pleural effusion sTREM-1 in patients with tuberculosis pleural effusion were significant higher than those in the other groups. Conclusion：It could be very important to differential diagnose inflammatory pleural effusion and non inflammatory pleural effusion by detecting sTREM-1.