血尿酸水平与老年代谢相关疾病的作用关系研究

The relationship between serum uric acid levels and metabolic diseases in elderly

目的：探讨血尿酸与老年患者代谢相关疾病的关系。方法：对本院2009~2010年体检中心60岁以上7 304例人群进行调查分析,通过病史询问、身高、体重测量、血压、血糖、血脂、尿酸等指标测定,分别按人群中男性和女性的血尿酸水平,以四分位数法将男女各分为4组。探讨尿酸水平与老年代谢相关疾病的相关性。结果：高尿酸血症老年男性各年龄段的发病率均高于女性,且血尿酸水平随年龄增加;体质指数（BMI）、收缩压、舒张压、空腹血糖（FPG）、血脂特别是甘油三酯（TG）及TG/HDL-C均随血尿酸水平的升高显著升高,呈线性趋势（P〈0.05）;老年高血压患者血尿酸水平与血压等级呈正相关;老年男性空腹血糖调节受损（IFG）患者血尿酸水平明显高于糖尿病患者,高尿酸血症组较非高尿酸组有较高的糖尿病发生率,在男性患者尿酸水平与空腹血糖呈正相关,但在女性患者这种相关性不明显;尿酸水平4组Logistic回归分析显示年龄、BMI、血压、血脂、空腹血糖与血尿酸水平升高呈显著正相关。结论：血尿酸水平与年龄、BMI、血脂异常、血压高、血糖高之间关系密切。因此,在老年群体中要重视对高尿酸血症的干预,减少心脑血管并发症。

Objective：To study the relationship between hyperuricemia and disease related to metabolic in the elderly. Methods： All 7304 adults above 60 years were enrolled in 2009 ~2010 at the medical examination center of the First Affiliated Hospital of NJMU. The medical history,the biochemical index and the general physical data were evaluated. The sex-specific cutoff for serum uric acid quartiles and multiple stepwise by multinomial Logistic regression model was used to analyze the relationship between uricemia and ages,sex,cholesterol,and other factors related to metabolism. Results：The incidence rates of hyperuricemia in men were higher than that in women at the same age group. The uric acid level increased with the ages. BMI,systolic blood pressure and diastolic blood pressure,fasting plasma glucose,especially TG and TG / HDL-C were positively correlated with blood uric acid（P 0.05）. The blood uric acid level was also positively correlated with blood pressure grades. Blood uric acid level of those with IFG was significantly higher than that of diabetic patients. The incidence of diabetes mellitus increased in hyperuricemia group than the nonhyperuricemia group. The blood uric acid level was positively associated with blood glucose in men,no such correlation observed in women. When the sex-specific cutoff for serum uric acid quartiles and multinomial Logistic regression model were used,the analysis revealed that ages,BMI,blood pressure,cholesterol,high density lipoprotein,cholesterol,TG / HDL-C,fasting plasma glucose and blood uric acid levels were significantly positive correlated. Conclusion：The blood uric acid level was closely related to ages,BMI, hyperlipidemia,hyperglycemia,hypertension and other constitution of metabolism. It is important to investigate the possible benefits of anti-hyperuricemia treatment for preventing complications in cardio-celebral-vascular system.