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心房肌电重构能促进房颤吗? 被引量：10

Does atrial myocardium electrical remodeling beget atrial fibrillation?
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摘要 Electrical remodeling in atrial fibrillation(AF)is considered to beget AF.However,in AF,decreased expressions of introverted ion currents INa and ICa channel proteins are corresponding to the induced increase of ion concentration in cells to maintain the membranes’polarity;ITo is phase 1 instantaneous extraverted K+current,IKur is the important extraverted K+current in phases 1 and 2,IKr,IKs are the main extraverted current in phase 2,and the ion channel proteins of them are down-regulated in AF to prolong atrial effective refractory period(AERP),which is disadvantageous to reentry;IK1,IKAch,IKATP work in phase 3,and their up-regulated channel proteins amplify myocardium diastolic potential,lower the myocardium excitability and reduce the ectopic excitement.Therefore,in AF,atrial electrical remodeling is not to beget AF,but to restore its physiological function.AF begets AF in that it can cause atrial structural remodeling,and the structural remodeling facilitates AF initiation and perpetuation.The interaction eventually aggravates atrial muscle injury and induces myocardial electrical disorder. Electrical remodeling in atrial fibrillation （AF） is considered to beget AF. However, in AF, decreased expressions of introverted ion currents INa and ICa channel proteins are corresponding to the induced increase of ion concentration in cells to maintain the membranes＂ polarity; ITo is phase 1 instantaneous extraverted K＊ current, IKur is the important extraverted K＊ current in phases I and 2, IKr, IKs are the main extraverted current in phase 2, and the ion channel proteins of them are down-regulated in AF to prolong atrial effective refractory period （AERP）, which is disadvantageous to reentry; IKI, IKAch, IKATP work in phase 3, and their up-regulated channel proteins amplify myocardium diastolic potential, lower the myocardium excitability and reduce the ectopic excitement. Therefore, in AF, atrial electrical remodeling is not to beget AF, but to restore its physiological function. AF begets AF in that it can cause atrial structural remodeling, and the structural remodeling facilitates AF initiation and perpetuation. The interaction eventually aggravates atrial muscle injury and induces myocardial electrical disorder.
作者 丁绍祥 柳茵 刘维军 李琳
机构地区 青海大学医学院 青海大学附属医院
出处 《医学争鸣》 CAS 北大核心 2014年第2期44-47,共4页 Negative
关键词 房颤 离子通道 电重构 结构重构 atrial fibrillation ion channel electrical remodeling structural remodeling
分类号 R541.75 [医药卫生—心血管疾病]
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参考文献20

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二级参考文献34

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共引文献13

同被引文献124

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引证文献10

二级引证文献24

医学争鸣
2014年 第2期

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