皮肤软纤维瘤继发鳞状细胞癌

A case of squamous cell carcinoma derived from skin fibroma molle

报告1例皮肤软纤维瘤基础上发生的鳞状细胞癌。患者女,65岁。左手臂皮肤袋状突起10年余,迅速增大6个月。皮肤科检查:左上臂伸侧有一2.5 cm×2 cm×2 cm暗红色不规则球形肿块,质中等,肿块随肢体活动可轻度扭转。皮损大体病理:球形肿块剖面呈灰白色,有蒂;组织病理:肿物表面多灶性坏死,瘤细胞呈巢团状向纤维组织内浸润,细胞核大、深染、多形,蒂部被覆皮肤基本完整,表皮角化过度,棘层肥厚,纤维组织增生部分变性,皮下见癌细胞浸润。诊断为皮肤软纤维瘤继发鳞状细胞癌。

A case of squamous cell carcinoma secondary to skin fibroma molle is reported. A 65-year-old woman com- plained of a skin lump on the left upper arm for over 10 years with rapid enlargement in the last 6 months. Physical exami- nation revealed an irregular spherical dark red mass on the extensor aspect of the left upper arm. It was about 2.5 cm×2 cm×2 cm in size and moderate firm. It twisted slightly with the movement of the limb. Pathological examination showed a gray lump with a pedicle. Microscopic examination revealed multifocal necrosis on the surface of the tumor. The tumor nuclei were large and dark stained in various shapes; Tumor cells infiltrated into fibrous tissue and were arranged in nests. The pedicle skin was almost intact with hyperkeratosis and acanthosis. There were fibroplasia with partial degeneration, and subcutaneous carcinoma cell infihration. The diagnosis was squamous cell carcinoma derived from skin fibroma molle.