妊娠瘙痒性荨麻疹性丘疹和斑块32例危险因素及对胎儿的影响

Risk Factors and Effects on Fetus of 32 Cases with Pruritic Urticarial Papules and Plaques of Pregnancy

目的探讨妊娠瘙痒性荨麻疹性丘疹和斑块(PUPPP)的病因及其对新生儿的影响。方法选取PUPPP患者32例和正常孕妇60例,比较其血清IgA,IgM和IgG水平;同时比较新生儿体重、男婴出生率及婴儿湿疹患病率。结果两组孕妇的血清IgA,IgM和IgG水平相当;两组男婴出生率差异也不明显;以上差异均无统计学意义(P均>0.05);患病组新生儿体重均高于对照组(P<0.05);另外,患病组婴儿湿疹患病率(37.50%)也高于对照组(21.67%),差异有统计学意义(P均<0.05)。结论 PUPPP发病可能同胎儿体重相关,但与胎儿性别无关;其有可能也促进了婴儿湿疹的发生。

Objective To explore cause and its effect of pruritic urticarial papules and plaques of pregnancy （PUPPP） on newborns. Methods A total of 32 patients and 60 normal pregnant women were selected and serum levels of the IgA, IgM, IgG, neonatal weight, prevalence of male birth rate and infantile eczema were com- pared. Results Serum IgA, IgM and IgG levels and prevalence of male birth rate were quite similar with no statistical difference （ P 〉 0. 05 ） in two groups. The neonatal weight of PUPPP group was higher than those of the normal control group （P 〈0. 05）. Besides,infantile eczema prevalence （37. 50% ） of PUPPP group was higher than that of control group （21.67%） ,with statistical significance （P 〈 0.05 ）. Conclusion PUPPP may be correlated with fetal weight, but it has nothing to do with the sex of the fetus. It may contribute to the occurrence of infantile eczema.