FLG基因与特应性皮炎

Filaggrin Gene and Atopic Dermatitis

特应性皮炎是一种慢性、复发性、炎症性皮肤病,以皮肤干燥和剧烈瘙痒为特征。特应性皮炎的发病被认为与表皮通透屏障功能缺陷及免疫失调相关,目前争论的焦点在于哪一个作为其发病的始动因素。FLG基因对维持皮肤屏障功能的角质层的形成和水合起关键作用,FLG基因的失功能性突变可能是影响特应性皮炎临床表现型和病情严重性的重要因素,但特应性皮炎患者中由于FLG基因突变引起的特征目前尚未确定,提示FLG基因的失功能性突变可能并非特应性皮炎的特异性突变。

Atopic dermatitis is a chronic, recurrent, inflammatory disease of the skin characterized by xerotic skin and severe itching. The pathogenesis of atopic dermatitis is considered to be related to the epidermal permeability barrier defects and immuine disorders. The current debate is that which one as the onset of the initial factor, FLG gene is critical to the formation and hydration of the stratum corneum responsible for the barrier function of the skin. FLG gene loss-of-function mutations, may be important factors that affect the clinical phenotype and the severity of atopic dermatitis . The characteristics of atopic dermatitis patients due to the FLG gene mutations are not yet to be determined,indicating that the FLG gene loss-of -function mutations may not the specific mutations of atopic dermatitis.