5-氨基酮戊酸光动力疗法联合胶原贴治疗中、重度痤疮30例临床观察

Observation of Photodynamic Therapy Combined with Collagen Mask in Patients with Moderate and Severe Acne

目的探讨5-氨基酮戊酸光动力疗法（ALA—PDT）联合胶原贴治疗中、重度痤疮的临床疗效和安全性。方法将入选的61例中、重度痤疮患者随机分为两组，治疗组（30例）予ALA—PDT联合胶原贴治疗，每7—10d1次，共治疗3—4次；对照组（31例）予红蓝光照射联合胶原贴治疗，2次／周，共治疗6—8次。治疗结束后判定疗效和安全性。结果治疗组有效率为83．33％，对照组为29．03％，差异有统计学意义（P〈0．01）。在治疗过程中，两组均未见不良反应。结论ALA—PDT联合胶原贴治疗中、重度痤疮较红蓝光联合胶原贴治疗的疗效好。安全性高。

Objective To investigate the efficacy and safety of photodynamic therapy using 5-aminovulinic acid com- bined with collagen mask in the treatment of moderate to severe acne. Methods Sixty-one patients were ran- domly assigned into two groups： the treatment group and the control group. The patients were treated with ALA-PDT combined with collagen mask in the treatment group, while the control group was treated with red/ blue light combined with collagen mask. All patients had 3 - 4 courses of treatment. The effects were evalua- ted after two months. Results The total effective rates were 83.33% in treatment group and 29. 03% in control group. The two groups had significant statistical difference （ P 〈 0. 01 ）. Both groups had no obvious side-effect during treatment. Conclusion The efficacy of ALA-PDT group is better than red/blue light group in the treatment of moderate to severe acne.