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维生素E聚乙二醇1000琥珀酸酯在药物制剂中的应用 被引量：6

Application of D-α-tocopheryl polyethylene glycol succinate 1000 in field of pharmaceutical formulations
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摘要 维生素E聚乙二醇1000琥珀酸酯(TPGS)作为一种重要的药用辅料,在药学领域应用广泛,可用于制备载体前体药物、胶束和固体分散体,修饰脂质体,并作为增溶剂、渗透促进剂、乳化剂、吸收促进剂等应用于制剂研究中。本文对TPGS的理化性质及其在药物制剂中应用的最新进展进行概述,为合理利用TPGS提供参考。 D-α-tocopheryl polyethylene glycol suecinate 1000 （TPGS） is a very useful pharmaceutical excipient in different kinds of preparations. It can be used to prepare carrier- prodrug, micelle and solid dispersion; to modify liposomal; also can be used as solubilizer, penetration enhancer, emulsifier, absorption enhancer. In this article, the physiochemical property and the recent development of TPGS in pharmaceutical preparation was classified and summarized in order to guide the correct use.
作者 庞鑫 翟光喜
机构地区 山东大学药学院
出处 《中国新药与临床杂志》 CAS CSCD 北大核心 2014年第4期247-251,共5页 Chinese Journal of New Drugs and Clinical Remedies
关键词 维生素E聚乙二醇1000琥珀酸酯 药用制剂 辅料 表面活性剂 D-α-tocopheryl polyethylene glycol succinate 1000 pharmaceutical preparations excipients surface-active agents
分类号 R94 [医药卫生—药剂学]
  • 相关文献

参考文献34

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共引文献18

同被引文献62

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中国新药与临床杂志
2014年 第4期

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