血清IL-18与原发性高血压及瘦素的相关性研究

The correlation research of IL-18 with essential hypertension and leptin

目的:研究高血压患者血清炎性细胞因子白介素-18(IL-18)与血清瘦素(Leptin)水平及其与炎症的相关性,研究临床意义。方法:测定血清IL-18、Leptin、C-反应蛋白(CRP),数据采用SPSS11.5软件包处理,结果以(均数±标准差)表示。结果:EH患者血清IL-18、Leptin、CRP水平显著高于对照组,并随血压分级增加而升高,差异有显著性意义(P<0.01)。结论:EH患者存在血清炎性细胞因子IL-18水平明显升高,且与血压分级相关,提示IL-18参与高血压的发生发展。EH患者血清Leptin水平升高且与血清IL-18及CRP呈正相关,提示Leptin可能在炎症方面参与高血压的发生。

Objective： To study serum levels of inflammatory cytokines interleukines18 together with Lep- tin and their correlations with inflammation in patients essential hypertension （EH）, and to investigate its clini- cal significance. Methods： We detected serum levels of IL-18, Leptin and CRP, and handled the data with SPSS11.5 soft- ware. The results presented as mean -4- standard deviation. Results： Serum levels of IL-18, Lpetin and CRP in EH patients were significantly higher than those observed in control subjects. Condusion. Inflammatory cytokine IL-18 serum levels are increased in patients with EH, which suggested that IL-18 participate in the development of hypertension. Serum Leptin levels increased in hypertensive patients, and were positively correlated with IL-18 and CRP, which suggested that Lpetin may participate in the incidence of hypertension in the aspect of inflammation.