CD147和MMP-9在喉鳞癌中的表达及意义

Expressions of CD147 and MMP-9 in laryngeal squamous cell carcinoma and their significance

目的探讨细胞外基质金属蛋白酶诱导因子(CD147)和基质金属蛋白酶-9(MMP-9)在喉鳞癌组织中的表达及临床意义。方法采用免疫组织化学染色法对36例喉鳞癌组织、癌旁组织及15例喉息肉组织中CD147和MMP-9的表达进行检测。结果①喉鳞癌组织中CD147的阳性率为83.3%(30/36),高于喉息肉(33.3%,5/15)和癌旁组织(16.7%,6/36);CD147的表达与喉癌病理分级、临床分期以及淋巴结转移状况有关(P<0.05)。②喉鳞癌组织中MMP-9的阳性率为72.2%(26/36),高于喉息肉(13.3%,2/15)和癌旁组织(5.6%,2/36);MMP-9的表达与喉鳞癌病理分级、T分级、临床分期以及淋巴结转移状况有关(P<0.05)。③CD147和MMP-9在喉鳞癌组织中的表达呈正相关(r=0.721,P=0.000)。结论 CD147和MMP-9在喉鳞癌中有较高的阳性表达,并可能与喉鳞癌的发展和转移有关。

Objective To investigate the expressions of CD147 and matrix metalloproteinases-9 （MMP-9） in laryngeal squamous cell carcinoma （LSCC） tissue and their clinical significance. Methods The expressions of CD147 and MMP-9 were analyzed semi-quantitatively by immunohistochemical staining in LSCC and control group tissues. Results ① The positive rate of CD147 was 83.3% （30/36） in LSCC, which was higher than that in laryngeal polyp （33.3%, 5/15） and in adjacent normal tissue （16.7%, 6/36）; it was related to histological grade, clinical stage and lymph node metastasis status （P〈0.05）. ② The positive rate of MMP-9 was 72.2% （25/36） in LSCC, which was higher than that in laryngeal polyp （13.3%, 2/15） and in adjacent normal tissue （5.6%, 2/36）; it was related to histological grade, T stage, clinical stage and lymph node metastasis status （P〈0.05）. ③ There was a positive correlation between the expressions of CD147 and MMP-9 in LSCC tissue （r = 0. 721, P = 0. 000）. Conclusion The over-expressions of CD147 and MMP-9 in LSCC may contribute to the development and metastasis of LSCC.