血清降钙素原和C-反应蛋白在评价溃疡性结肠炎病情中的临床价值

Clinical significance of serum procalcitonin and C-reaction protein in the patients with ulcerative colitis

[目的]探讨血清降钙素原(PCT)和C-反应蛋白(CRP)在评价溃疡性结肠炎病情中的临床价值。[方法]检测120例溃疡性结肠炎患者(病例组)和30例健康体检者(正常对照组)外周血PCT和CRP水平。[结果]病例组缓解期、活动期患者PCT水平分别为(1.56±0.36)μg/L、(6.57±2.96)μg/L,均明显高于正常对照组[(0.33±0.16)μg/L],P<0.01;病例组缓解期、活动期CRP水平分别为(6.78±3.85)mg/L、(23.46±12.53)mg/L,均明显高于正常对照组[(0.68±0.23)mg/L],P<0.01;活动期患者PCT、CRP水平缓解期患者(P<0.01)。病例组轻度、中度、重度病情患者PCT水平分别为(3.64±1.78)、(5.67±2.75)、(8.96±1.86)μg/L,CRP水平分别为(8.75±3.64)、(22.78±6.57)、(31.45±11.34)mg/L;中度、重度病情患者的PCT、CRP水平均明显高于轻度者(P<0.01),重度病情患者PCT、CRP水平均明显高于中度者(P<0.01)。[结论]血清PCT和CRP水平可能成为评价溃疡性结肠炎病情活动及严重程度的辅助指标。

[Objective]To approach on clinical value of serum procalcitonin （PCT）and C-reactive protein （CRP） in diagnosis of ulcerative colitis（UC）. [Methods]The PCT and CRP levels in 120 UC patients and 20 healthy volunteers were measured. [Results]The levels of serum T PCT and CRP levels in active UC and catabolic UC were higher than control group（E1.56±0. 36]vs[0. 33±0.16]μg/L,[6.57±2. 96]vs[0. 33± 0. 16]μg/L,[6.78±3. 85]vs[0. 68±0. 23]mg/L, [23.46±12.53]vs[0. 68±0. 23]mg/L;P〈0. 01）. The level of serum T PCT and CRP in active UC were higher than catabolic UC（[6. 57±2.96]vs[1.56±0. 36] μg/L, [23.46± 12. 53]vs[6.78±3.85]mg/L; P〈0.01）. The levels of serum T PCT and CRP in severe and moderate UC group were higher than the mild group（[8. 96±1.86]vs[3.64±1.78]μg/L, [5. 67±2. 75]vs [3.64±1.78]t^g/L, [31, 45±11. 34]vs[8. 75±3. 64]mg/L,[22.78±6. 57]vs[8. 75±3. 64]mg/L;P〈 0.01）and severe group of patients PCT and CRP levels were higher than moderate patients（ [8. 96±1. 861 vs[5.67±2. 75]μg/L, [31.45±11. 34]vs[22. 78± 6. 57]mg/L; P〈0. 01）. [Conclusion]Serum PCT and CRP levels may be a potential marker in the evaluation of UC severity.