复方玄驹胶囊对Ⅲ型前列腺炎合并勃起功能障碍的疗效探讨

Therapeutic efficacy of compound Xuanju capsule on type-Ⅲ prostatitis-related erectile dysfunction

目的观测复方玄驹胶囊对Ⅲ型前列腺炎合并勃起功能障碍(ED)的临床疗效。方法选择伴有性功能障碍的Ⅲ型前列腺炎患者198例,将患者分为对照组(105例)及治疗组(93例)。对照组口服左氧氟沙星0.2 g,每天2次,连续服用4周;口服甲磺酸多沙唑嗪2 mg,每晚1次,连续服用2个月。治疗组在上述治疗的基础上,同时口服复方玄驹胶囊3粒,每天3次,连续服用2个月。采用慢性前列腺炎症状指数(NIH-CPSI)评分、国际勃起功能指数问卷5(IIEF-5)评分进行治疗前后疗效比较。结果所有患者均无严重不良反应出现,能坚持服药。治疗后2个月重新评分,对照组NIH-CPSI(17.1±5.4)分,较治疗前(24.8±4.9)分显著改善(P<0.05);IIEF-5(12.9±5.1)分,较治疗前(11.7±4.7)分有所增加,但差异无统计学意义(P>0.05)。治疗组NIH-CPSI(13.3±5.6)分,IIEF-5(17.6±6.3)分,与治疗前比较,均改善显著(P<0.05)。对照组ED总有效率21.0%,治疗组ED总有效率75.3%,差异有统计学意义(P<0.05)。结论复方玄驹胶囊治疗Ⅲ型前列腺炎伴发ED,既可明显改善慢性前列腺炎症状,同时对伴发的ED也有较好的疗效,无严重不良反应。

Objective To evaluate the clinical value of compound Xuanju capsule on the treatment of type - m prostatitis - related erectile dysfunction. Methods 198 type - III prnstatitis patients with sexual dysfunction diagnosed by NIH clinical criteria were randomly divided into a control （ n = 105 ） and a treatment group （ n = 93 ）. The former group were treated with oral levofloxacin 0.2g b/d for 4 weeks and oral doxazosin mesylate at 2 rng qn for 2 months ,and the latter group plus with oral Compound Xuanju Capsule once 3 capsules rid for 2 months. The therapeutic results were analyzed based on the NIH - Chronic Prostatitis Symptom Index （ NIH- CPSI） and the International Index of Erectile Function （ IIEF - 5）, and the baseline data were compared between the two groups. Results None of the patients had serious medication - related adverse reactions. After treatment, the control group showed significantly decreased on NIH - CPSI scores and slightly increased on IIEF -5 scores compared with the baseline （ 17.1 ±5.4 vs. 24.8 ±4.9,P 〈 0.05 and 12.9±5.1 vs. 11.7 ±4.7 ,P 〉0.05） ,while the treatment group exhibited significant improvement in both NIH - CPSI （ 13.3 ± 5.6 vs. 24.4 ± 5.2, P 〈 0.05 ） and IIEF - 5 scores （ 17.6± 6.3 vs. 10.4 ±3.5,P 〈 O. 05 ）. The total effectiveness rate for ED was significantly higher in the treatment than that in the control group （75.3% vs. 21.0% ,P 〈 0.05 ）. Conclusion Compound Xuanju capsule can significantly alleviate both the symptoms in the treatment of type - III prostatitis - related erectile dysfunction.