渗出性年龄相关性黄斑变性患者的屈光状态

Refraction state of patients with exudative age-related macular degeneration

目的探讨渗出性年龄相关性黄斑变性(AMD)患者与非AMD健康者屈光状态的差异。设计病例对照研究。研究对象筛选并纳入136例渗出性AMD患者具有屈光状态记录的247眼,其中154只患眼作为渗出性AMD组,包括34例双眼渗出性AMD患者的67眼及102例单眼渗出性AMD患者的87眼。选取北京德胜社区非AMD正常受试者中与渗出性AMD患者年龄、性别匹配的136例,纳入具有屈光状态的242眼作为对照组。方法采用电脑验光后显然验光的方法测量纳入眼的屈光度。远视标准定义为>+0.5 D。比较两组患者的屈光状态。主要指标屈光状态与屈光度。结果渗出性AMD组远视72眼(46.7%),屈光度(四分位数间距)为+0.50(-0.38,+1.25)D。对照组远视74眼(30.6%),屈光度为+0.13(-1.13,+0.84)D。渗出性AMD组较对照组远视眼比例高(P<0.001),渗出性AMD组较对照组更倾向于远视(P<0.001)。结论渗出性AMD患者较非AMD健康者可能更倾向于发生远视,且远视的度数更高。

Objective To investigate the difference of the refraction between patients with exudative age-related macular degenera- tion （AMD） and non-AMD populations. Design Case-control study. Participants A total of 247 eyes with refraction information from 136 exduative AMD patients were recruited. 154 eyes with AMD as exduative AMD group, in which 67 eyes were from 34 biocular AMD patients, 87 eyes were from 102 monocular AMD patients. A number of 242 non-AMD eyes （136 non-AMD subjects who were age and sex matched with the AMD group） were recuited from Beijing Desheng Region as control group. Methods Refractions were mea- sured by auto refractor and non mydriatic optometry. Hyperopia standard defined as more than ＋0.5 D. The refractions were compared between the two groups. Main Outcome Measures Refraction state and degree. Results The frequencies of hyperopia in AMD group were 46.7% （72 eyes）, the refractions of interquartile range was ＋0.50 （-0.38, ＋1.25 ）D. The frequencies of hyperopia were 30.6% （74 eyes） in control group, meanwhile the refractions of interquartile range was ＋0.13 （-1.13, ＋0.84）D. The refractions of AMD group were inclined to higher hyperopia than control group （P〈0.001）. Also, there were higher hyperopia frequencies of AMD group than control group （P〈0.001）. Conclusion Compared with non-AMD populations, exudative AMD patients may be inclined to be a higher hyperopia.