摘要
根据T细胞受体的不同,人体T淋巴细胞分为αβT细胞和γδT细胞。近年αβT细胞共刺激信号在调节T细胞活化及耐受方面的研究取得了重要的进展,而在γδT细胞相关的研究较少。明确这些共刺激分子及其信号通路在γδT细胞免疫应答的不同阶段发挥的不同正向负向调节作用,将为病毒感染、肿瘤、自身免疫性疾病、移植后排斥等疾病的治疗提供新的前景。
Human T lymphocytes are divided into αβT cells and γδTcells on the basis of the different expressions of T cell receptors. In recent years, the studies of the regulation of T cell activation and tolerance by co-stimulatory molecules and their signaling pathways in αβT cell have made remarkable progress ; however, relatively fewer investigations have been performed on γδT cells. A clearer understanding of the roles of co-stimulatory molecules and their signaling pathways in the positive/negative regulation of γδT cells at different stages will provides new insights for the treatment of viral infections, cancer, autoimmune diseases, transplant rejection, and other conditions.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2014年第2期223-226,共4页
Acta Academiae Medicinae Sinicae
基金
国家自然青年科学基金(81101707)
浙江省中医药基金(2011ZA104)
嘉兴科技计划项目(2012AY1071-2)~~