三七总皂苷多组分释药同步性考察

Study on the release synchronicity of multi-component of Panax notoginseng saponins

目的:研究三七总皂苷缓控释制剂中3种主要成分释放曲线的同步性。方法:测定3种主要成分在水中的溶解速率;制备三七总皂苷微孔渗透泵片、亲水凝胶骨架片、水不溶性骨架片、溶蚀型骨架片等缓控释剂型,测定在水中的累积释放度,采用f2因子法评价累积释放曲线的相似性。结果:三七总皂苷3种成分在水中溶解曲线相似;溶蚀型骨架片、不溶型骨架片、微孔膜渗透泵片及亲水凝胶骨架片3种成分累积释药曲线相似度依次降低。结论:三七总皂苷溶蚀型骨架片及不溶性骨架片3种成分释放同步性较好。

OBJECTIVE To study the release synchronicity of three main ingredients of Panax notoginseng saponins （PNS） extended release preparations. METHODS The dissolution rate of ginsenoside Rgl , ginsenoside Rb1 , and notoginsenoside R1 in water was determined. The different kinds of extended release dosage form were prepared. Then the accumulated release of these three main ingredients in water was determined. Finally, the similarity of release profiles with f2 factors was estimated. RESULTS The dissolution rates of these three ingredients were similar in water, and the similarity of accumulated drug-re- lease curve of the these three ingredients decreased in turn as erodible matrix tablets, water-insoluble matrix tablets, micro-por- ous membrane osmotic pump tablets and hydrophilic gel matrix tablets. CONCLUSION The release synchronicity of three main ingredients of PNS of erodible matrix tablets and water-insoluble matrix tablets are better.