胰岛素样因子3及其在多囊卵巢综合征中的作用

Research of the Insulin-like Factor 3 on the Polycystic Ovary Syndrome

胰岛素样因子3(INSL3)既往被称为松弛素样因子,男性主要由睾丸间质细胞分泌,女性主要由卵巢卵泡膜细胞分泌。最近有研究发现,多囊卵巢综合征(PCOS)患者特别是非肥胖的PCOS患者,INSL3浓度较正常人明显升高,这被认为是与黄体生成激素依赖性卵巢高雄激素血症有关。综述INSL3基因及分子结构、受体(新型G蛋白耦联受体LGR8/GREAT)在女性中的生理学作用,INSL3对PCOS患者发生和发展的重要影响。

The insulin-like factor 3 （INSL3）,previously known as the relaxin-like factor,is encoded by the INSL3 gene in human. It is secreted from the testicular leydig cells of adult men as well as the theca interna cells of ovarian follicles in adult female. Recent studies have found that INSL3 circulating levels in patients with polycystic ovary syndrome are significantly higher than that in normal people,especially in those patients who are not overweight,which possibly due to the reason of luteinizing hormone dependent hyperandrogenism. This paper describes the INSL3 gene and its molecular structure,its receptor （a novel G-protein-coupled receptors LGR8/GREAT）,the physiological function in female,with particular emphasis on the vital influence of pathogenesis and pathophysiology of polycystic ovary syndrome caused by INSL3.