男性乳腺癌与女性乳腺癌患者临床病理特征对比

The clinicopathological difference between male and female breast cancer

目的：探讨男性乳腺癌（male breast cancer，MBC）与女性乳腺癌（female breast cancer，FBC）患者临床病理特征的不同。方法回顾性分析2003年6月至2013年6月期间郑州大学第一附属医院37例男性乳腺癌及随机抽取（将6853例FBC排序后应用小飞侠随机抽取器软件V5.1.2版随机抽取）的300例女性乳腺癌的临床病理资料。结果 MBC的中位年龄较FBC大（t＝3.117，P＝0.002），MBC与同期FBC例数之比为0.54％（37∶6853）；MBC病理类型以浸润性导管癌为主（χ2＝7.535，P＝0.023）；临床分期Ⅲ期与Ⅳ期患者较FBC多（χ2＝16.471，P＝0.000）；MBC患者雌激素受体（estrogen receptor，ER）阳性率明显高于FBC患者（χ2＝6.294，P＝0.043），而人类表皮生长因子受体（human epidermal receptor 2，HER2）明显低于FBC患者（χ2＝11.222，P＝0.004）。 MBC的手术方式以改良根治为主，目前未行保乳手术，而FBC的手术方式较多（χ2＝7.720，P＝0.021）。结论男性乳腺癌和女性乳腺癌不管从临床病理特点还是手术治疗方式，甚至预后情况均不一致，了解其病理特征是临床治疗的前提。

Objective To compare the clinical-pathology features between male breast cancer （ MBC） and female breast cancer（FBC）patients.Methods Clinical data of 37 MBC and 300 FBC patients admitted in the First Affiliated Hospital of Zhengzhou University from Jun .2003 to Jun.2013 was retrospectively reviewed . Results The ratio of MBC to FBC was 54：10000.The age of MBC patients ranged from 39 to 80 years with the median age of 62 years old, older than FBC patients（t=3.117, P=0.002）.The percentage of invasive ducal carcinoma was much higher in MBC patients than in FBC patients （χ2 =7.535,P=0.023）.MBC patients in clinically stage III and IV were more than FBC patients （χ2 =16.471,P=0.000）.The positive rate of estrogen receptor（ER）was significantly higher in MBC patients than in FBC patients （χ2 =6.294,P=0.043）.The posi-tive rate of human epidermal growth factor receptor-2 （ HER2 ） was lower in MBC patients than in FBC patients （χ2 =11.222,P=0.004）.The main surgical method of MBC was modified radical mastectomy , and there was no breast-conserving surgery for MBC, while the surgical method of FBC was various （χ2 =7.720,P=0.021）. Conclusion There are significant differences between FBC and MBC patients in clinicopathological features , surgical method and even prognosis , which were important to guide the treatment of MBC and FBC .