小而密低密度脂蛋白与冠心病关系的研究

The relationship between small, dense low density lipoprotein and coronary heart disease

目的观察冠心病（CHD）患者血清小而密低密度脂蛋白（sdLDL）的水平，探讨sdLDL与CHD的关系。方法采用2％。16％的非查性梯度胶电泳检测经冠脉造影证实的50例CHD患者sdLDL水平，用30例冠脉造影阴性者和30例健康人作为对照，观察各组间的变化，采用多元逐步回归统计分析，以了解CHD危险因素对sdLDL的影响。结果冠脉造影阳性组的血清sdLDL（56．2＋11．3）％明显高于对冠照阴性（41．5±10．0）％（P〈0．01）与健康对照组（40．3±918）％（P〈0．01）；sdLDL异常组血清TG水平增高，HDL—C水平降低，均与正常组存在显著差异（P〈0．01）。结论血清sdLDL测定可作为预测CHD危险性的指标。

ObJective To rnvestigate the serum levels of small, dense low density lipoprotein （sdLDL） in patients with coronary heart disease （CHD）,and the relationghip of them. Methods The serum levels of sdLDL were detected by 2%-16% non-denatur- ing gradient gel eleefirophoresis＇ in 50 CHD patients Who were diagnosed by coronary angiography, 30 subjects with negative coro- nary angiography and 30 healthy volunteers, respectively. The impact of CHD risk factors on sdLDL was investigated by muhivari- ate stepwise regression analysis as well. Results The serum levels of sdLDL in CHD group （56.2±11.3） % were higher than that in coronary angiography negative group （41.5±10.0）% and normal controls （40.3±9.8） %. Serum TG levels in high sdLDL group were significantly higher than that in normal sdLDL group （P〈0.01）. And HDL-C levels in high sdLDL group were significantly lower than that in normal sdLDL group （P〈0.01）： Conclusion sdLDL may be a new indicator and risk factor of CHD.