摘要
[ Objective] The paper was to study antioxidant effects of L-carnitine （LC） on rabbit, and explore its impact on SOD, GSH-PX, CAT, T-AOC and MDA activity in the plasma, brain tissue and cerebrospinal fluid of rabbit. [ Method] The healthy matured New Zealand rabbits with big ears were intragastrically administrated with LC at the dose of lmL/kg, and SOD, GSH-PX, CAT, T-AOC and MDA activities in plasma, brain tissue and cerebrospinal fluid of rabbit were determined at different periods before and after administration, respectively. [Result] After LC administration, SOD, GSH-PX CAT, and T-AOC activity in plasma, brain tissue and cerebrospinal fluid increased significantly （P 〈 0.05 ）, while MDA content decreased significantly （P 〈 0.05）. [Condusion ] LC oral solution shows antioxidant effects on rabbit.
[ Objective] The paper was to study antioxidant effects of L-carnitine （LC） on rabbit, and explore its impact on SOD, GSH-PX, CAT, T-AOC and MDA activity in the plasma, brain tissue and cerebrospinal fluid of rabbit. [ Method] The healthy matured New Zealand rabbits with big ears were intragastrically administrated with LC at the dose of lmL/kg, and SOD, GSH-PX, CAT, T-AOC and MDA activities in plasma, brain tissue and cerebrospinal fluid of rabbit were determined at different periods before and after administration, respectively. [Result] After LC administration, SOD, GSH-PX CAT, and T-AOC activity in plasma, brain tissue and cerebrospinal fluid increased significantly （P 〈 0.05 ）, while MDA content decreased significantly （P 〈 0.05）. [Condusion ] LC oral solution shows antioxidant effects on rabbit.
基金
Supported by Science and Technology Development Plan of Yantai City(2011074)
Shandong Provincial Natural Science Foundation,China(ZR2010HL068)
