摘要
目的:研究微孔淀粉吸附丁香挥发油的特性。方法:采用微孔淀粉吸附丁香挥发油,考察微孔淀粉用量对丁香酚收率、溶出度和热稳定性的影响。结果:微孔淀粉和挥发油质量比为2.5∶1时,固化粉末中丁香酚收率达到(91.03±0.56)%,丁香酚体外溶出度增加,热稳定性改善。结论:微孔淀粉适于固化丁香挥发油,具有推广价值。
Objective： To characterize the adsorption capacity of microporous starch, taking clovevolatile oil as the model drug. Methods： The yield and dissolution rate of eugenol from different ratio ofmicroporous starch were evaluated, meanwhile the thermal stability of eugenol was studied. Results： Theyield of eugenol was up to （91.03±0.56）% when solidification ratio of microporous starch to volatile oil was2.5：1; meanwhile the dissolution rate of eugenol was increased and the thermal stability was improved afterabsorption by porous starch. Conclusion： The above results proved that the microporous starch is suitablefor solidifying clove volatile oil, which paved the preliminary way for the study of microporous starch asabsorbent and solidifying excipient.
出处
《药学与临床研究》
2014年第1期47-49,共3页
Pharmaceutical and Clinical Research
关键词
微孔淀粉
丁香挥发油
溶出度
稳定性
Microporous starch
Clove volatile oil
Dissolution rate
Stability
