^(18)F-FDG PET-CT显像在诊断鼻咽癌放疗后早期复发的应用价值

Value of ^(18)F-FDG PET-CT in detecting early recurrence of nasopharyngeal carcinoma after radiotherapy

目的探讨18F-脱氧葡萄糖(18 F-FDG)正电子发射型计算机断层扫描(PET-CT)在诊断鼻咽癌放疗后早期复发的临床应用价值。方法回顾性分析57例鼻咽癌放疗后患者18 F-FDG PET-CT和MRI影像学资料,根据组织病理学检查和临床随访结果分为复发组(43例)和未复发组(14例)。结果 18F-FDG PET-CT诊断原发性鼻咽癌早期复发的灵敏度、准确率和阴性预测值均高于MRI(97.6%vs.75.4%、91.2%vs.85.4%和90.9%vs.50.0%)(P<0.05)。复发组肿瘤的标准摄取值(SUV)高于未复发组(7.98±3.29vs.3.31±2.09)(P<0.05)。结论 18 F-FDG PET-CT在诊断鼻咽癌放疗后早期复发上是一种可靠的临床诊断工具。

Objective To investigate the clinical value of 18 F-FDG PET-CT in detecting early recurrence of nasopharyngeal carcinoma（NPC） after radiotherapy. Methods Data of 57 patients with NPC after radiotherapy were retrospectively analyzed, who were examined with 18 F-FDG PET-CT and MRI and assigned into two groups of A （with recurrence, 43 cases） and B （without recurrence, 14 cases）. Results The sensitivity,accuracy rate and negative prediction rate in detecting the recurrence of post-radiation NPC by 18F-FDG PET-CT were significantly higher than those by MRI（97. 6% vs. 75.4%,91.2% vs. 85.4% and 90. 9% vs. 50.0%）（P〈0. 05）. The average standardized uptaken value（SUV） in group A was higher than that in group B（7. 98±3. 29 vs. 3.31±2.09） （P〈0. 05）. Conclusion In detecting early recurrence of NPC after radiotherapy,18 F-FDG PET-CT can be considered as a reliable tool of clinical diagnosis.