血栓抽吸导管联合替罗非班在老年急性ST段抬高性心肌梗死患者的临床研究

Efficacy of thrombus aspiration catheter combined with triofiban in therapy on elderly patients with acute ST-segment elevation myocardial infarction

目的探讨血栓抽吸导管联合替罗非班治疗老年急性ST性段抬高型心肌梗死患者的临床疗效。方法选择2011年2月-2012年6月我院行急诊经皮冠状动脉介入（PCI）治疗的老年（年龄〉65岁）急性ST段抬高性心肌梗死患者60例，经冠状动脉造影证实为有血栓负荷，随机分为应用替罗非班联合血栓抽吸导管治疗为治疗组（30例），同期应用替罗非班未联合血栓抽吸导管治疗为对照组（30例）。比较两组术后患者的心肌梗死血管血流变化（TIMI分级）、术后心肌灌注分级（TMPG）、术后ST段回落程度、出血性并发症和住院期间不良事件（MACE）的发生率。结果治疗组患者即刻（TIMI）血流、术后心肌灌注分级（TMPG）、术后ST段回落程度、住院期间不良事件（MACE）的发生率明显优于对照组，致命性出血两组无统计学差异。结论血栓抽吸导管联合替罗非班在老年急性ST段抬高性心肌梗死患者应用安全和有效。

Objective To research the effect of thrombus aspiration Catheter combined with Triofiban therapy on elderly patients with Acute ST-segment elevation Myocardial Infarction. Methods From Feb 2011 to Jun 2012 sixty aged patients more than 65 with STMI and thrombotic burden lesion confirmed by coronary angiography who underwent primary perculaneous coronary artery（PCI） treatment were enrolled in the study.The patients were divided into two groups at random;The treatment group received Catheter combined with Triofiban,The control group had no receiving Catheter combined with Triofiban.Then the differences of thrombolysis in myo-cardial infarction（TIMI） Flow grade,TIMI myocardial perfusion grade（TMPG）and major adverse cardiac events （MACE）in hospital and MACE were compared between two groups. Results The number of patients with three graded TIMI flow and TMPG after the therapy in the treatment group less than control group,MACE incidencein hospital and MACE in 12 months and fatal hemorrhagic complications have no significantly differences in two groups. Conclusion Application of thrombus Aspiration Catheter combined with Triofiban therapy on elderly Patients with Acute Myocardial Infarction was effective and safely.