JAM-1在子宫内膜癌组织中的表达及意义

Expression and significance of JAM-1 in tissues of endometrial carcinoma

目的探讨JAM-1在不同肌层浸润深度的子宫内膜癌组织中的表达及意义。方法 73例子宫内膜癌患者,其中癌细胞无肌层浸润18例,浅层浸润38例,深层浸润17例,采用免疫组化法检测JAM-1在无、浅、深三组浸润深度的表达情况。结果 JAM-1表达在子宫内膜癌癌细胞、腺细胞的胞膜及胞浆,随肌层浸润程度的增加JAM-1的表达显著减弱,差异有统计学意义(P<0.05)。结论子宫内膜癌JAM-1的表达与癌细胞的浸润程度呈反比,提示JAM-1可能与子宫内膜癌的浸润、侵袭相关。

Objective To investigate the expression and significance of JAM-1 in the endometrial carcinoma tissues with different myometrial invasion depth. Methods Seventy-three patients with endometrial carcinoma were selected, of which 18 patients were without myometrial invasion, 28 patients had superficial invasion and 17 patients had deep invasion. The immunohistochemistry was used to detect the expression situation of JAM-1 in the three groups with no superficial and deep invasion. Results JAM-1 expressed in the cancer cells of endometrial carcinoma and cell membrane and cytoplasm of glandular cells. As the depth of myometrial invasion increased, the expression of JAM-1 weakened significantly, with statistically significant differences（P 〈 0.05）. Conclusion In endometrial carcinoma, the expression of JAM-1 and invasion depth of cancer cells are negatively correlated, suggesting that JAM-1 may be associated with the invasion of endometrial carcinoma.