盐酸贝那普利联合硝苯地平控释片不同给药时间的降压疗效观察

Observation of depressurization efficacy of benazipril hydrochloride combined with nifedipine controlled release tablets administered at different time

目的探讨盐酸贝那普利联合硝苯地平控释片不同给药时间的降压疗效。方法选取2011年3月～2013年3月我院进行治疗的高血压患者115例，按照随机数字分为A、B、C三组。结果三组加服比索洛尔5mg的比率比较，差异不显著（P〉0．05）。各组的24hSBP、24hDBP、24hMABP、dSBP、dDBP、dMABP、nSBP、nDBP、nMABP与治疗前血压比较，均显著下降，差异显著（P〈0．05）。三组血压下降值比较，A组与c组间nSBP、nDBP、nMABP比较差异显著（P〈0．05）；B组与C组间nDBP、nDBP、nMABP比较差异显著（P〈0．05）。平滑指数比较，A组与c组nSBP、nDBP、nMABP差异显著（P〈0．05），B组与C组nSBP、nDBP、nMABP比较差异显著（P〈0．05）。结论依那普利与硝苯地平联合用药能更好地控制老年患者的血压，降压效果十分优越，具有极高的临床应用价值。

Objective To investigate the depressurization efficacy of benazepril hydrochloride combined with nifedipine controlled release tablets administered at different time. Methods 115 patients with hypertension treated in our hospital from March 2011 to March 2013 were selected and divided into group A, group B and group C according to the random number. Results The three groups were not significantly different in the ratio of additional administration of visoprolol 5mg, with no significant difference（P 〈 0.05）. The 24hSBP, 24hDBP, 24hMABP, dSBP, dDBP, dMABP, nSBP, nDBP and nMABP of each group after treatment reduced significantly compared to those before treatment, with significant differences（P 〈 0.05）. In terms of the drop-out value of blood pressure, group A and group C were significantly different in nSBP, nDBP and nMABP（P 〈 0.05）; group B and group C were significantly different in nDBP, nDBP and nMABP（P 〈 0.05）. In terms of smoothness index, group A and group C were significantly different in nSBP, nDBP and nMABP（P 〈 0.05）; group B and group C were significantly different in nSBP, nDBP and nMABP（P 〈 0.05）. Conclusion Benazepril hydroehloride combined with nifedipine controlled release tablets can better control the elder patients＇ blood pressure, has excellent depressurization effect and is of quite high clinical application value.