低分子肝素治疗急性冠脉综合征对于外周血血细胞膜表面组织因子的影响分析

The peripheral blood cell surface tissue factor effects analysis of low molecular weight heparin for treating acute coronary syndrome

目的观察低分子肝素治疗急性冠脉综合征对于外周血血细胞膜表面组织因子的影响。方法急性冠脉综合征患者80例根据随机抽签原则分为观察组与对照组各40例,两组都给予常规治疗,观察组在此基础上给予低分子肝素钙注射治疗。结果观察组和对照组的总有效率分别为91.25%和71.25%,观察组的总有效率明显高于对照组(P<0.05)。两组治疗前的外周血血细胞膜表面组织因子表达对比差异无统计学意义,治疗后表达量都明显降低(P<0.05),同时组间对比差异也有统计学意义(P<0.05)。两组治疗过程中都无严重不良反应情况的发生。结论低分子肝素治疗急性冠脉综合征有很好的疗效与安全性,其作用的发挥与降低外周血血细胞膜表面组织因子表达有关。

Objective To observe the peril^heral blood cell surface tissue factor effects of low molecular weight heparin for treating acute coronary syndrome. Methods 80 patients with acute coronary syndrome accorded to the principles were randomly divided into the observation group and the control group, all cases were treated with conventional therapy, and the observation group were added given low molecular weight heparin injection treatment. Results The total efficiency of the observation group and the control group were 91.25% and 71.25% respectively （P 〈 0.05）.The peripheral blood cell surface tissue factor expression before treatment compared between the groups showed no significant difference,after treatment these values were significantly lower（P 〈 0.05）, while inter-group compared were statlstical!y significant differences（P 〈 0.05）. Both groups during the treatment had no serious adverse reactions. Conclusion The low molecular weight heparin in the treatment of acute coronary syndrome has better efficacy and safety,it plays the value may be relats to reduce peripheral blood cell surface tissue factor expression.