丹红注射液在冠心病不稳定型心绞痛中的应用观察

Application observation of Danhong injection in coronary heart disease unstable angina

目的观察丹红注射液治疗冠心病不稳定型心绞痛的临床效果。方法选取我院2012年1月～2013年12月间收治的冠心病不稳定型心绞痛患者100例，随机分为对照组和观察组，均给予常规治疗，在此基础上，对照组加用硝酸甘油注射液，观察组加用丹红注射液治疗，比较两组临床疗效及治疗前后血液流变学参数及内皮功能改善情况。结果观察组患者治疗总有效率明显高于对照组（P〈0．05），治疗后患者血浆黏度、纤维蛋白原、红细胞沉降率及红细胞压积等血液流变学参数改善程度均明显优于对照组（P〈0．05），FMD、NO、ET-1水平改善程度明显优于对照组，差异均具有统计学意义（P〈0．05）。结论丹红注射液治疗冠心病不稳定型心绞痛疗效显著，可有效改善患者血液流变学及内皮功能，值的临床推广应用。

Objective To observe the clinical effect of Danhong injection in the treatment of coronary heart disease unstable angina. Methods One hundred patients with coronary heart disease unstable angina admitted to our hospital from January 2012 to December 2013 were selected and randomly divided into the control group and the observation group. Both groups received conventional treatment,on the basis of which the control group was given additional nitroglycerin injection and the observation group was given Danhong injection. The clinical efficacy and pre-treatment and post-treatment hemorheological parameters and endothelial function improvement conditions of the two groups were compared. Results The observation group had significantly higher total effective rate than the control group（P 〈 0.05）. After treatment,the observation group had significantly better improvement degrees in plasma viscosity,fibrinogen,erythrocyte sedimentation rate,hematocrit and other hemorheological parameters than the control group（P 〈 0.05） and significantly better improvement degree in FMD,NO and ET-1 levels than the control group,with statistically significant differences（P 〈 0.05）. Conclusion Danhong injection shows significant efficacy in the treatment of coronary heart disease unstable angina and can effectively improve the patients＇ hemorheological parameters and endothelial function,thereby worthy of clinical promotion and application.