期刊文献+

抗结核药物所致重度肝损伤40例分析 被引量:3

Analysis of 40 patients with antituberculosis drug-induced severe liver injury
下载PDF
导出
摘要 目的探讨抗结核药物致重度肝损伤的治疗和预防。方法分析2012年12月~2013年12月住院的40例重度抗结核药物引起的重度肝损伤的临床资料。结果40例抗结核药物引起的重度肝损伤俱在2个月内肝功能恢复正常。结论抗结核药物引起的重度肝损伤尽管危害性大,只要熟悉掌握抗结核药物的副反应制定合理治疗方案,及时并定期复查肝功能,重度肝损伤是可以治疗和预防的。 Objective To explore the treatment and prevention of antituberculosis drug-induced severe liver injury. Methods Clinical data of 40 patients with antituberculosis drug-induced severe liver injury who were hospitalized from December 2012 to December 2013 were analyzed. Results The liver function of all the 40 patients returned to normal within 2 months. Conclusion Although the damage brought by antituberculosis drug-induced severe liver injury is large, development of rational treatment regimen after mastering the side effects of antituberculosis drugs and regular reexamination of liver function can treat and prevent severe liver injury.
作者 伏志杰
出处 《中国医药科学》 2014年第6期204-205,共2页 China Medicine And Pharmacy
关键词 抗结核药物 重度肝损伤 肝功能 Antituberculosis drug Severe liver injury Liver function
  • 相关文献

参考文献12

  • 1Sharma SK.Antituberculosis drugs and hepatotoxicity[J].InfectGenet Evol,2004,4(2):167-170.
  • 2Devarbhavi I4,Singh R,Patil M,et al.Outcome anddeteminants of mortality in 269 patients with combination antituberculosis drug-induced liver injury[J].J Gastroenterol Hepatol,2013,28(1):161-167.
  • 3杨慧媛,宋育林,许建明.抗结核药物肝毒性研究现状及其存在的问题[J].安徽医药,2008,12(4):289-292. 被引量:20
  • 4陈成伟.药物性肝损伤的发病机制及其处理[J].中华结核和呼吸杂志,2013,36(10):726-728. 被引量:25
  • 5贾忠,吴晶,马建军,梁云,刘渊,王兴刚.一线抗结核药物肝损害的研究现状[J].中国防痨杂志,2013,35(6):468-471. 被引量:45
  • 6Yee D,Valiquette C,Pelletier M,et al.Incidence of serious side effects from firest-line antituberculosis drugs among patients treated for active tuberculosis[J].Am J Respir Crit Care Med,2003,16(2):1472-1477.
  • 7Chang KC,Leung CC,Yew WW,et al.Hepatotoxicity of pyrazinamide:cohort and case-control analyese[J].Am J Respir Crit Care Med,2008,17(3):1391-1396.
  • 8卜建玲,高微微,谢莉,郑素华.药物性肝损害高危人群抗结核治疗方案的探讨[J].中国防痨杂志,2009,31(2):91-93. 被引量:21
  • 9Kumar R,Shalimar,Bhatia V,et al.Antituberculosis therapyinduced acute liver failure:magnitude,profile,prognosis,and predictors of outcome[J].Hepatology,2010,51(2):1665-1674.
  • 10Ostapowicz G,Fontana Pal,Schiodt FV,et al.Resuhs of a prospective study of acute liver failure at 17 tertiary care centers in the United States[J].Ann Intern Med,2002,12(03):947-954.

二级参考文献100

共引文献131

同被引文献34

引证文献3

二级引证文献34

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部