摘要
MicroRNAs （miRNAs） are endogenous small non-coding RNAs that repress their targets at post transcriptional level.Existing studies have shown that miRNAs are important regulatory genes in hepatocellular carcinoma （HCC）,as either tumor suppressors or oncogenes.MiR-122 is normally downregulated in HCC and regarded as a tumor suppressor.Recently miR-122 has been reported to be regulated by CEBPA,which is then involved in a novel pathway to influence proliferation of tumor cells.However it is unknown whether CEBPA is regulated by miRNAs in HCC.In this study,we find that miR182 is upregulated in HCC model rat,and represses CEBPA in both rat and human.This further improves the current CEBPA/miR-122 pathway that controls the proliferation of tumor cells.These results suggest that miR-182 is a potential oncogene in HCC and could be used as a diagnostic marker and drug target of HCC.
MicroRNAs （miRNAs） are endogenous small non-coding RNAs that repress their targets at post transcriptional level.Existing studies have shown that miRNAs are important regulatory genes in hepatocellular carcinoma （HCC）,as either tumor suppressors or oncogenes.MiR-122 is normally downregulated in HCC and regarded as a tumor suppressor.Recently miR-122 has been reported to be regulated by CEBPA,which is then involved in a novel pathway to influence proliferation of tumor cells.However it is unknown whether CEBPA is regulated by miRNAs in HCC.In this study,we find that miR182 is upregulated in HCC model rat,and represses CEBPA in both rat and human.This further improves the current CEBPA/miR-122 pathway that controls the proliferation of tumor cells.These results suggest that miR-182 is a potential oncogene in HCC and could be used as a diagnostic marker and drug target of HCC.
基金
supported in part by a start-up grant of Kunming University of Science and Technology given to Yun Zheng
a major projects of Shanghai Municipal Health Bureau(No.20100222) given to Xiaolin Wang
a Youth Fund of Zhongshan Hospital,Fudan University(No.201102) given to Chenggang Wang
