明胶海绵微粒栓塞治疗肝转移癌

Gelatin sponge particles in transcatheter arterial chemoembolization for treatment of metastatic liver cancer

目的评价采用明胶海绵微粒（GSPs）进行TACE治疗肝转移癌的临床疗效。方法回顾性分析36例接受350-560μm明胶海绵微粒TACE治疗的肝转移癌患者的临床资料，评价疗效、肝功能损伤、不良反应及生存率。结果中位随访时间15个月，肿瘤均有不同程度坏死及缩小；完全缓解2例、部分缓解27例、稳定5例、进展2例，客观反应率80．55％（29／36）；术后7天肝功能基本恢复至术前水平，无严重并发症发生；6个月生存率91．67％（33／36）、12个月生存率83．33％（30／36）。结论采用GSPs进行TACE治疗肝转移癌近期疗效良好。

Objective To evaluate the clinical efficacy of transcatheter arterial chemoembolization （TACE） with gelatin sponge particles （GSPs-TACE） for treatment of metastatic liver cancer. Methods Data of 36 patients with metastatic liver cancer who received GSPs-TACE were retrospectively analyzed. Tumor responses, liver function, adverse reaction and sur- vival rate were evaluated. Results The median follow-up time was 15 months. Necrosis with different degree in the lesions and reduction of the tumors were observed during follow-up. Complete response was achieved in 2 patients, partial re- sponse was obtained in 27, stable disease was found in 5 patients, while progressive disease was detected in 2 patients, and the obective response rate was 80.55% （29/36）. Seven clays after GSPs-TACE, liver function recovered to the level before operation. No severe complications occurred. The 6-and 12-month survival rate of this group was 91.67% （33/36） and 83.33% （30/36）, respectively. Conclusion Short-term efficacy of GSPs-TACE in treatment of metastatic liver cancer is good.