摘要
Thl7细胞是近年来发现的一种不同于Thl、Th2细胞的CD4＋效应性T细胞亚群，以分泌IL-17为特点。Thl7细胞与梅毒、淋病及艾滋病的发病机制具有一定的相关性。Thl7细胞数目在梅毒螺旋体及淋球菌感染者体内存在变化，但Thl7细胞是否有利于梅毒及淋病的病情控制尚有争议。HIV感染者存在外周血Thl7和Treg细胞的不平衡，Thl7细胞比例较低，机体自发地控制病毒进展，需要保持Thl7／Treg的平衡，而Thl7细胞水平升高有利于控制病情。
T helper 17 （Thl7） cells, a new subset of CD4＋ effector T cells different from Thl and Th2 cells, are characterized by the secretion of interleukin-17 （IL-17）, and associated with the pathogenesis of syphilis, gonorrhea and acquired immunodeficieney syndrome （AIDS）. The number of Th17 cells is abnormal in patients with syphilis and gonorrhea, but whether Thl7 cells helps to control syphilis or gonorrhea remains controversial. The proportion of Th17 cells is decreased and there is an imbalance between Th17 cells and regulatory T （Treg） cells in peripheral blood of patients with human immunodeficiency virus （HIV）. To up- regulate the levels of Thl7 cells and maintain the balance between Th17 cells and Treg cells is essential for the host to fight against HIV infection spontaneously.
出处
《国际皮肤性病学杂志》
2014年第3期180-183,共4页
International Journal of Dermatology and Venereology
