一些含三氮杂茂偶氮染料O,N供体的Zr(Ⅱ)配合物的合成、表征和抗微生物活性(英文)

Synthesis, Characterization and Antimicrobial Efficiency of Some Zirconyl(Ⅱ) Complexes Involving O, N-Donor Environment of Triazole-Based Azodyes

合成了9种3-(2-羟基萘基-1-偶氮)-1,2,4-三氮唑(HL1),3-(2,4-二羟苯基-1-偶氮)-1,2,4-三氮唑(HL2),3-(2-羟基-3-羧基萘基-1-偶氮)-1,2,4-三氮唑(HL3),3-(2-羟基-5-溴苯基-1-偶氮)-1,2,4-三氮唑(HL4)和3-(2-羟基-5-甲基苯基-1-偶氮)-1,2,4-1,2,4-三氮唑(HL5)的Zr(Ⅱ)配合物并用元素分析,摩尔电导,磁矩,IR,UV-Vis,1H-NMR以及热分析(TGA和DTA)对其进行了表征。结果表明HL1-HL5以二齿一元配体方式通过偶氮的氮原子和羟基基团的氧原子与Zr(Ⅱ)离子配位生成单核配合物。用4种革兰氏阴性菌,即大肠杆菌(Escherichia coli),粘质沙雷氏菌(Serratia marcescens),阴沟肠杆菌(Enterobacter cloacae)和普通变形杆菌(Proteus vulgaris),以及2种真菌,即白色念珠菌(Candida albicans)和黑曲霉菌(Aspergillus niger)对配体及其配合物的生物学活性进行了研究。最小抑菌浓度(MICs)用纸上杯碟琼脂扩散法测定,结果表明在大多数情况下,金属化的配合物的抗微生物活性与自由配体相比有所增强。

Nine zirconyl（ll） complexes of 3-（2-hydroxynaph-l-ylazo）-l,2,4-triazole （HL1）, 3-（2,4-dihydroxyphen-1- ylazo）-l,2,4-triazole （HL2）, 3-（2-hydroxy-3-carboxynaph-l-ylazo）-l,2,4- triazole （HL3）, 3-（2-hydroxy-5-bromophen- 1-ylazo）-l,2,4-triazole （HL4） and 3-（2-hydroxy-5-methylphen-l-ylazo）-l,2,4-triazole （HL5） have been synthesized and characterized by elemental analysis, molar conductance, magnetic moment and spectroscopic data （IR, electronic and 1H-NMR） as well as thermal analyses （TGA and DTA）. The results show that HL1-HL5 coordinate to zirconyl（ll） ions as bidentate monobasic ligands through the azo nitrogen and the oxygen of hydroxyl group yielding mononuclear complexes. The biological activity of the ligands and their complexes were studied on four Gram-negative bacteria Escherichia coli, Serratia marcescens, Enterobaeter cloacae and Proteus vulgaris and two Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus as well as two fungi Condida albicans and Aspergillus niger. The minimum inhibitory concentrations （MICs） of the prepared compounds were determined by agar diffusion assay using filter paper disc diffusion method. In most cases, metallization increases the antimicrobial activity compared with the free ligand.