氧化应激反应在OSAHS伴原发性高血压中的作用

The effect of oxcdative stress on obstructive sleep apnea-hypopnea syndrome combined with hypertension

目的:检测OSAHS患者血清中生物活性物质一氧化氮(NO)、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)的水平,探讨其在OSAHS伴原发性高血压过程中的作用。方法:收集99例夜间睡眠打鼾的患者,分为对照组、OSAHS组及OSAHS伴高血压组,检测手术前后患者血清中NO、SOD、GSH的水平,并进行相关性分析。结果:与对照组相比,OSAHS组、OSAHS伴高血压组患者血清中NO、SOD、GSH水平明显降低,与AHI、最低血氧饱和度呈负相关;手术治疗后患者血清中NO、SOD、GSH水平提高,血压下降。结论:OSAHS患者体内存在严重氧化应激反应,OSAHS伴高血压的患者表现得更为明显,氧化应激反应在OSAHS伴原发性高血压的发生、发展过程中有一定作用。

Objective：To detect the levels and effects of protective bioactive substances such as NO, SOD and GSH in patients with obstructive sleep apnea syndrome （OSAHS） combining hypertension. Method：To collect the data from 99 snoring patients, which were divided into control group, OSAHS group, and OSAHS combined with hypertension group. The serum levels of NO, SOD and GSH in these patients were detected perioperatively, correlation analysis were carried out between these parameters . Result：The levels of NO, SOD and GSH in control group, OSAHS group and OSAHS combined with hypertension group reduced in turn with statistically significance, and had inverse correlations with apnea hyponea index（AHI） and lowest saturation of blood oxygen. After operation, the levels of NO, SOD and GSH were increased and the blood pressure was decreased. Conclusion：The oxidative stress state is serious in patients with OSAHS. The oxidative stress process is more severe in patients with hypertension,which may play a role in the devolepment of hypertension in OSAHS patients.