经支撑喉镜平阳霉素注射治疗喉咽巨大血管瘤12例临床研究

Pingyangmycin injection under suspension laryngoscopy for giant hemangioma at Hypopharynx and laryngeal in 12 cases

目的:探讨经支撑喉镜平阳霉素注射治疗下咽及喉部巨大血管瘤的方法及疗效。方法:12例下咽及喉部巨大血管瘤患者术前行多导睡眠监测,在全身麻醉下常规行气管切开术,经口插入支撑喉镜进入咽喉部声门区,经长管针行血管瘤体内注射平阳霉素(每3周注射1次,总剂量<50mg)。结果:治愈10例,显效2例。术后经多导睡眠监测显示患者缺氧较术前明显改善。经1年以上的随访,未见复发。结论:该方法治疗下咽及喉部巨大血管瘤风险小、安全性高、喉功能保存好、治疗彻底,能改善患者缺氧,提高其生活质量,是治疗咽喉巨大血管瘤的一种理想方法。

Objective：To explore the therapeutic methods and effect of pingyangmycin injection in huge hemangioma at Hypopharynx and laryngeal under suspension laryngoscopy. Method： To ananysize the medical records of 12 Patients with giant hemangioma at hypopharynx and laryngeal. Patients were underwent polysomnography before operation. Inseted the suspension laryngoscopy to pars laryngea by mouth to exposing the hemangioma under general anaesthesia, then injected PingyangmYcin by a long-tube needling （one time per three weeks, accumulated dose less than 50 mg）. Result.. Among all patients, ten were cured and two showed obvious improvement. The data of PSG after operetion indicates that the symptom of anoxia of post-operation were significantly ameliorated than that of pre-operation, no recurrence occurred during one year follow-up of the hemangioma. Conclusion：The methods of pingyangmycin injection under suspension laryngoscopic surgery is significantly enhanced clinical effect and improved the life quality of patients with huge hemangioma, which with low risk, high security, can ameliorating anoxia, complete cure, and is a ideal therapeutic measure.