摘要
人参是一种典型的适应原,它的作用与下丘脑-垂体-肾上腺系统(HPA)轴内分泌系统有关。皂苷是人参中的主要有效成分,具有与固醇类激素相似的结构。本文结合适应原的定义和HPA轴调节作用的规律,从总皂苷和皂苷单体两方面探讨了人参对HPA轴作用的影响,并总结了其药理作用与HPA轴作用的关系。
Ginseng is a typical adaptogen which has resistance to various stresses. This effect is related to the hypothalamic-pituitary-adrenal （HPA） axis. As the main active ingredients, saponin has the similar structure to steroids. The regulation characteristics of ginseng saponin on the HPA axis are narrated from the aspects of total saponin and saponin monomers in this paper after the introduction of adaptation definition and HPA axis regulation mechanisms. Pharmacological effects of ginseng saponin and the regulation effect of HPA axis are summarized finally.
出处
《药学学报》
CAS
CSCD
北大核心
2014年第5期569-575,共7页
Acta Pharmaceutica Sinica
基金
国家“重大新药创制”科技重大专项资助项目(2011ZX09401-305-07)
关键词
人参
皂苷
适应原
HPA轴
应激
ginseng
saponin
adaptogen
hypothalamic-pituitary-adrenal axis
stress
