摘要
醛氧化酶(aldehyde oxidase,AOX)是一类高度保守的钼-黄素蛋白,主要存在于哺乳动物细胞质中,具有广泛的底物特异性,可催化醛类及含氮、含氧杂环类化合物的氧化反应。该酶体内分布较广,存在种属及个体间差异,在药物及外源物的I相代谢中发挥重要作用。本文将简要介绍AOX的生物学特性及在药物代谢中的作用。
Aldehyde oxidase （AOX）, a highly conserved molybdoflavoenzyme in mammal cytoplasm, has broad substrate specificity and ability to catalyze the oxidation of aldehydes and nitrogen, oxygen-containing heterocyclic rings. AOX was found to widely distribute with the individual differences in vivo and plays an important role in phase I metabolism of drugs and xenobiotics. The biological characteristics of AOX and its contributions in drug metabolism are introduced briefly in this review.
出处
《药学学报》
CAS
CSCD
北大核心
2014年第5期582-589,共8页
Acta Pharmaceutica Sinica
基金
十二五新药创制重大专项(2012ZX09301002-001-007,2012ZX09301002-006,2012ZX09103-101-001)
国家自然科学基金资助项目(81072696)
关键词
醛氧化酶
药物代谢
钼-黄素蛋白
aldehyde oxidase
drug metabolism
molybdoflavoenzyme
