雷公藤多苷联合胰激肽原酶治疗糖尿病肾病的疗效观察

Tripterygium Glycosides Combined Effect of Pancreatic Kininogenase in Treating Diabetic Nephropathy

目的探讨雷公藤多苷联合胰激肽原酶对2型糖尿病肾病的影响。方法选择65例2型糖尿病肾病患者,随机分为2组:观察组35例和对照组30例,在常规降糖、血管紧张素受体拮抗剂降压、降蛋白等治疗的基础上,对照组加用胰激肽原酶口服,观察组在对照组基础上给予雷公藤多苷治疗。结果 2组治疗后总有效率相比,差异有统计学意义(P<0.05)。2组经治疗后24 h尿蛋白定量下降,但治疗组下降更为明显,与对照组相比差异有统计学意义(P<0.05);治疗组血尿素氮及肌酐下降较对照组明显(P<0.05),治疗组血清白蛋白较治疗前上升(P<0.05)而对照组不明显。结论雷公藤多苷联合胰激肽原酶可有效减少2型糖尿病肾病患者的蛋白尿水平。

Objective To explore the effects of tripterygium glycosides combined with kallidinogenase on diabetic nephropathy in type 2 diabetes mellitus. Methods The 65 cases of type 2 diabetic patients with nephropathy,were randomly divided into 2 groups ：35 cases in observation group and 30 cases in the control group, based on routine hypoglycemie, angiotensin receptor antagonist, reduced protein antihypertensive treatment, the control group were treated with pancreatic kininogenase oral, the observation group in the control group based on the given twp treatment. Results After the treatment in the 2 groups in the total effective rate, the difference was statisti- cally significant（ P 〈 0.05 ）. The 2 groups after treatment,24 h decreased urinary protein excretion, but the treatment group decreased more significantly, compared with the control group ,the difference was statistically significant（ P 〈 0.05） ;treatment group,blood urea nitrogen and creatinine decreased significantly compared with the control group （ P 〈 0.05 ）, serum albumin increased compared with those before treatment（ P 〈 0.05 ）and the control group was not obvious. Conclusion Tripterygium wilfordii combined with pancreatic kininogenase can effectively reduce the level of proteinuria in patients with type 2 diabetic nephropathy.