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不同DPP-4抑制剂的构效关系和药代动力学特征 被引量:4

Relationship between structure and efficiency of different dipeptidyl peptidase-4 inhibitors and their pharmacokinetic characteristics
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摘要 二肽基肽酶-4(DPP-4)抑制剂是治疗2型糖尿病的新靶点,强效和选择性DPP-4抑制剂已成为糖尿病治疗新药的开发热点。本文主要对已在国内上市的西格列汀、沙格列汀、维格列汀和利格列汀4种DPP-4抑制剂的构效关系以及药代动力学特点,吸收、分布、代谢、消除进行综述。
作者 陈忻 翟所迪
出处 《药品评价》 CAS 2014年第7期15-20,共6页 Drug Evaluation
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  • 1The global dominance of diabetes[J]. Lancet, 2013 Nov 23, 382(9906): 1680.
  • 2Xu Y, Wang L, He J, et al. Prevalence and Control of Diabetes in Chinese Adults[J]. JAMA, 20! 3, 310(9): 948-959.
  • 3Baetta R, Corsini A. Pharmacology of Dipeptidyl Peptidase- 4Inhibitors[J]. Drugs, 2011, 71(11): 1441-1467.
  • 4Zerilli T, Pyon EY. Sitagliptin phosphate: a DPP-4 inhibitor for the treatment of type 2 diabetes mellitus[J]. Clin Ther, 2007, 29(12): 2614- 2634.
  • 5http://www.ema.europa.eu/docs/en_GB/document library/EPAR- Product_ Information/human/000722/WC500039054.pdf.
  • 6Bergman A J, Ebel D, Liu F, et al. Absolute bioavailability of sitagliptin, an oraldipeptidyl peptidase-4 inhibitor, in healthy volunteers[J]. Biopharm Drug Dispos, 2007, 28(6): 315-322.
  • 7Bergman AJ, Stevens C, Zhou Y, et al. Pharmacokinetic and pharmacodynamics properties of multiple oral doses of sitagliptin, a dipeptidyl peptidase-IV inhibitor: a double-blind, randomized, placebo- controlled study in healthy male volunteers[J]. Clin Pharmacol Ther, 2006, 28(1 ): 55-72.
  • 8Herman GA, Stevens C, Van Dyck K, et al. Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo -controled studies with single oral doses[J]. Clin Pharmacol Ther, 2005, 78(6): 675-688.
  • 9Herman GA, Bergman A, Stevens C, et al. Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose level after an oral glucose tolerance test in patients with type 2 diabetes [J]. J Clin Endocrinol Metab, 2006, 91 (11 ): 4612-4619.
  • 10Migoya EM, Stevens C, Bergman A, et al. Effect of moderate hepatic insufficiency on the pharmacokinetics of sitagliptin[J]. Can J Clin Pharmacol, 2009, 16(1 ): e 165-170.

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