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抗Scl-70抗体检测与临床应用 被引量:8

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摘要 系统性硬皮病(Systemic scleroderma,SSc)是累及皮肤和内脏的免疫复合物疾病.有不同程度的纤维化、血管病变及炎症性改变,临床常分为肢端硬皮病和弥漫性硬皮病两型[1].抗Scl-70抗体靶抗原为碱性非组蛋白,为DNA局部异构酶Ⅰ亦称拓扑异构酶Ⅰ的降解产物,因最初仅在系统性硬化病患者中发现该抗体,且其抗原分子量为70 000,故称抗Scl-70抗体.我们对48例系统性硬皮病患者进行了抗Scl-70抗体的检测,结果报告如下.
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2014年第4期533-534,共2页 Chinese Journal of Immunology
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参考文献5

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  • 2王兰兰.自身抗体检测的应用与质量保障原则[J].中华检验医学杂志,2005,28(10):987-990. 被引量:43
  • 3鞠少卿,王旭东,王跃国,仲人前,王惠民.悬浮阵列技术在研究与临床中的应用[J].中华检验医学杂志,2006,29(5):393-396. 被引量:10
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  • 6Martial Koenig,Mélanie Dieudé,Jean-Luc Senécal.Predictive value of antinuclear autoantibodies: The lessons of the systemic sclerosis autoantibodies[J]. Autoimmunity Reviews . 2008 (8)
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  • 8Sulli Alberto,Soldano Stefano,Pizzorni Carmen,Montagna Paola,Secchi Maria Elena,Villaggio Barbara,Seriolo Bruno,Brizzolara Renata,Cutolo Maurizio.Raynaud’s phenomenon and plasma endothelin: correlations with capillaroscopic patterns in systemic sclerosis. The Journal of rheumatology . 2009
  • 9Bussone Guillaume,Bérezné Alice,Pestre Vincent,Guillevin Lo?c,Mouthon Luc.The scleroderma kidney: progress in risk factors, therapy, and prevention. Current rheumatology reports . 2010
  • 10Saketkoo LA, Matteson EL, Brown KK. Developing disease ac- tivity and response criteria in connective tissue disease- relatedinterstitial lung disease [J]. J Rheumatul, 2011, 38 (7): 1514-1518.

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