以太冲为主穴同名经配穴对自发性高血压大鼠降压效应观察

Anti-hypertension Effect of Selecting Taichong(LR3) as the Major Point plus Its Common-meridian Acupoint on Rats with Spontaneous Hypertension

目的观察以太冲为主穴的同名经配穴对自发性高血压大鼠(SHR)的降压效应,探讨穴位配伍对经穴效应的影响。方法将90只SHR大鼠分为模型组、非穴组、太冲组、内关组、太冲配内关组、太冲配非穴组,每组15只。毫针刺入穴位后,留针30 min,每日1次,共15次;模型组不予针刺。各组大鼠分别在针刺1 d、3 d、7 d、15 d时进行血压测量。结果非穴针刺无明显降压作用。针刺3 d、7 d、15 d时,太冲组、内关组、太冲配非穴组、太冲配内关组收缩压(SBP)、舒张压(DBP)、平均动脉压(MBP)降压幅度与模型组比较差异均有统计学意义(P<0.01,P<0.05);针刺15 d时,太冲配内关组SBP、DBP、MBP降幅分别优于太冲组、内关组、太冲配非穴组,差异均有统计学意义(P<0.01,P<0.05)。与治疗前相比,针刺1 d、3 d、7 d、15 d时,太冲配内关组大鼠SBP、DBP、MBP下降均有统计学意义(P<0.01,P<0.05),其中针刺15 d时SBP、DBP、MBP降幅优于针刺1 d、3 d、7 d,差异均有统计学意义(P<0.01)。结论以太冲配内关的同名经配穴针刺降压效应优于单穴及太冲配非穴,同时发现针刺降压作用具有一定的累积效应。

Objective To observe the anti-hypertension effect of selecting Taichong（LR3） as the major point plus its common-meridian acupoint on the spontaneous hypertension rat（SHR）, and to explore the effect of acupoint compatibility on the action of acupoints. Method Ninety SHRs were randomized into a model group, a non-acupoint group, Taichong group, Neiguan（PC6） group, Taichong plus Neiguan group, and Taichong plus non-acupoint group, 15 rats in each group. The acupuncture needles were retained in acupoints for 30 min, once every day, 15 times in total; the model group didn＇t receive acupuncture treatment. The blood pressure was examined on the day 1, 3, 7, and 15 of the acupuncture treatment. Result The non-acupoint group didn＇t show significant anti-hypertension effect. On the day 3, 7, and 15 of the acupuncture treatment, the reductions of systolic blood pressure（SBP）, diastolic blood pressure（DBP）, and mean arterial blood pressure（MBP） of Taichong group, Neiguan group, Taichong plus non-acupoint group, and Taichong plus Neiguan group were significantly different from those of the model group（P0.01,P 0.05）; on the day 15, The reductions of SBP, DBP, and MBP of Taichong plus Neiguan group were superior to those of Taichong group, Neiguan group, and Taichong plus non-acupoint group（P0.01,P0.05）. On the day 1, 3, 7, and 15, the reductions of SBP, DBP, and MBP in Taichong plus Neiguan group were statistically significant（P0.01,P0.05）, and the reductions on the day 15 were significantly better than those on the day 1, 3, and 7（P0.01）. Conclusion Acupuncture at Taichong and Neiguan has better anti-hypertension effect than acupuncture at single acupoint or at Taichong plus non-acupoint. Meanwhile, it＇s found that the anti-hypertension effect of acupuncture is an accumulative effect.