5年生种植人参对成年大鼠心功能和血流动力学的影响

The Effect of 5-year-old planting ginseng on cardiac function and hemodynamics in adult rats

目的观察5年生种植人参食用对成年大鼠心功能和血流动力学的影响,探讨人参食用对机体心血管系统功能的调节作用。方法正常成年Wistar大鼠随机分为10组,即:对照组,5年生种植人参原粉小、中、大剂量(0.25、0.5、1.0g生药/kg)组,5年生种植人参水提物小、中、大剂量(0.25、0.5、1.0g生药/kg)组,5年生种植人参醇提物小、中、大剂量(0.25、0.5、1.0g生药/kg)组,每组14只。各组大鼠连续灌胃给药3个月,观察心功能和血流动力学变化。结果与对照组比较,人参原粉和人参醇提物可使正常成年大鼠动脉收缩压(SBP)、左室收缩压(LVSP)、左心室内压最大上升和下降速率(±dp/dtmax)均明显增高(P<0.05或P<0.01),对舒张压(DBP)、平均动脉压(MAP)、左心室舒张末压(LVEDP)及心率(HR)均无明显影响(P>0.05)。人参水提物各剂量组对SBP、DBP、MAP、LVSP、±dp/dtmax、LVEDP及HR均无明显影响(P>0.05)。结论人参原粉和人参醇提物对正常成年大鼠具有明显的正性肌力(强心)作用,人参水提物对正常成年大鼠的血压及心脏心收缩和舒张功能均无增强或降低作用。

Objective To observe the effect of 5-year-old planting ginseng on cardiac function and hemodynamics in adult rats, and to investigate the regulation of body＇s cardiovascular function through the edible of ginseng. Methods Normal adult Wistar rats were randomly divided into 10 groups： control group, the low, medium,high-dose groups of original powder of 5-year-old planting ginseng （0.25,0.5 and 1.0g crude drug / kg）; the low, medium, high-dose groups of water extract from 5-year-old planting ginseng （0.25,0.5 and 1.Og crude drug / kg）; the low, medium, high-dose group of ethanol extract from 5-year-old planting ginseng （0.25,0.5 and 1.0g crude drug / kg）, fourteen rats for each group.The rats were administered orally three consecutive months, and observed the changes of cardiac function and hemodynamics. Results Compared with the control group, Systolic Blood Pressure （SBP）, Left Ventricular Systolic Pressure （LVSP） and Left Ventricular Pressure maximal rate of rise and fall （±dp/dtmax） were significantly higher in group of ginseng original powder and ethanol extract from ginseng （P〈0.05 or P〈0.01） but had no significant effect on Diastolic Blood Pressure （DBP）,Mean Arterial Pressure （MAP）, Left Ventricular end-diastolic Pressure （LVEDP） and Heart Rate （HR）. Each dose group of ginseng water extract had no significant effect on SBP, DBP, MAP, LVSP, ±dp/dtmax, LVEDP and HR （P〉0.05）. Conclusion Original powder and alcohol extract from ginseng have obvious positive inotropic effect in normal adult rats, but water extracts from ginseng have no increasing or decreasing effect on blood pressure and Cardiac ventricular systolic and diastolic function in normal adult rats.