摘要
[目的]研究不同的制剂辅料对芒果苷口服吸收的影响。[方法]采用人源结肠腺癌细胞系Caco-2细胞模型,考察制剂辅料(羟丙基-β-环糊精,聚乙二醇4000,聚乙二醇6000)对芒果苷在Caco-2细胞模型中吸收转运的影响。[结果]随着辅料浓度的增加,羟丙基-β-环糊精和聚乙二醇4000能改变芒果苷在Caco-2细胞模型中的渗透方向率PDR;而聚乙二醇6000则使芒果苷的渗透方向率PDR增大。[结论]羟丙基-β-环糊精和聚乙二醇4000能促进芒果苷的口服吸收;而聚乙二醇6000则无此作用。
[objective] To study the effect of different pharmaceutical excipient on mangiferin oral absorption. [Methods] Hu- man colon adenocarcinoma cell line (Caco-2 cell) was used as a cell model to investigate the effect of pharmaceutical excipients (hydroxypropyl-β-cyclodextrin, PEG4000, PEG6000)on absorption and transportation in Caco-2 cell model of mangifcrin. [ Results ] With the increase of excipients concentration, hydroxypropyl-β-cyclodextrin and PEG4000 could invert the permeability direction (PDR) of mangiferin in Caco-2 cell model, while PEG6000 increased permeability direction (PDR) of mangifein. [Conclusions] Hydroxypropyl-β-cyclodextfin and PEG4000 are beneficial to mangiferin absorption, while PEG6000 not.
出处
《广西中医药大学学报》
2014年第1期60-62,共3页
Journal of Guangxi University Of Chinese Medicine
基金
国家自然科学基金项目(81260666)
广西自然科学基金项目(2011GXNSFB018077)
广西中药药效研究重点实验室课题(10-046-04-Z10)
广西高等学校特色专业及课程一体化建设项目
关键词
芒果苷
辅料
CACO-2细胞模型
吸收转运
Mangiferin
Excipient
Caco-2 cell model
absorption and transportation