经静脉给予小剂量咪达唑仑对经皮冠状动脉介入患者的抗焦虑作用

Antianxiety effect of small dose of midazolam by vein on patients with percutaneous coronary intervention

目的:探讨经静脉注射小剂量咪达唑仑对经皮冠状动脉介入患者的抗焦虑作用。方法:将300例有经皮冠状动脉介入指征的患者随机分为干预组和对照组,给对照组和干预组患者分别于术前30 min和术后30 min发放焦虑自评量表。对照组术前不给任何镇静药物,干预组于术前5 min经静脉给予咪达唑仑2 mg(1 mg/mL),分别记录两组于手术前一天、术前5 min、术中10 min、手术结束时心率、血压以及血氧饱和度。结果:干预组术前和术后焦虑自评量表评分较对照组显著下降,术中和术后的血压和心率亦显著下降。结论:经静脉小剂量给予咪哒唑仑可明显减轻经皮冠状动脉介入手术患者的焦虑情绪,并抑制由于焦虑情绪而导致的血压升高和心率加快。

Objective： To determine the antianxiety effect of small dose of midazolam by vein on patients with percutaneous coronary intervention（PCI）. Methods： Altogether 300 patients subjected to PCI were randomly divided into a control group and a study group, and a survey was made in the two groups by Self- Rating Anxiety Scale （SAS） Questionnaire 30 min before and after the operation. The patients in the control group were not given to any tranquilizing drugs, but the patients in the study group were given midazolam 2 mg（1 mg/mL）. The blood pressure, heart rate, and SPO2 were recorded at the 1st day, 5 min before the operation, 10 min during the operation and at the end of the operation. Results： The SAS-scores in the study group were less than those in the control group after the operation. The blood pressure and heart rate in the study group decreased more than those in the control group during and at the end of the operation. Conclusion： Small dose of midazolarn can ease the anxiety and fear of patients, and prevent the increase of blood pressure and heart rate induced by anxiety and tension moods.