活性氧与肾纤维化的研究进展

Progress in study on reactive oxygen species and renal fibrosis

肾纤维化是各种慢性肾疾病进行性发展的主要病理基础,活性氧在肾纤维化的发生和发展中扮演着重要的角色。有关抗氧化治疗肾纤维化的研究较多,N-乙酰半胱氨酸、血管紧张素转换酶抑制剂、氟非尼酮、维生素E等被认为有一定的肾保护作用,这也为肾纤维化的临床防治提供新的研究方向和治疗靶点。

Renal fibrosis is a major histological feature in many chronic kidney diseases. More and more studies have demonstrated that reactive oxygen species play significant role in the development of renal fibrosis. The therapeutical effect of drugs with antioxidative activities on renal fibrosis is well studied. N-acetylcysteine, angiotensin-converting enzyme inhibitors, fluorofenidone and vitamin E are able to protect kidney, at least partially, from fibrosis, which may provide novel thoughts for therapeutic targets of renal fibrosis.