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双特异性蛋白磷酸酶6在肿瘤中作用的研究进展

Progress in study on DUSP6 in the tumor
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摘要 双特异性蛋白磷酸酶6(dual specificity phosphatases 6,DUSP6)是一种双特异性蛋白磷酸酶,主要是负反馈调控反转录病毒相关的DNA序列-细胞外信号调节激酶1/2(retrovirus associated DNA sequences-extracellular signal regulated kinase,RAS-ERK1/2)信号通路。而DUSP6对于RASERK1/2信号转导通路的负反馈调节一旦打破,就可能会引起肿瘤,甚至还会出现恶性分化。近年来DUSP6在肿瘤形成、浸润、转移和肿瘤治疗方面的作用,已成为新的研究热点,能有助于许多恶性肿瘤的临床病理的诊断及治疗预后的判断。 Dual specificity protein phosphatase 6（DUSP6 ） is a dual specificity protein phosphatase, which exerts an important negative feedback effect on retrovirus associated DNA sequences-extracellular signal regulated kinase （RAS-ERK1/2） signaling pathway. Once the negative feedback regulation is broken, it may cause cancer, or even malignant differentiation. In recent years, DUSP6 has become a new hotspot in tumor formation, invasion, metastasis and treatment, which may have value in clinical diagnosis and prognosis for many malignant tumors.
作者 冯琨 肖明明 景士兵
机构地区 辽宁省人民医院病理科
出处 《临床与病理杂志》 CAS 2014年第2期206-211,共6页 Journal of Clinical and Pathological Research
关键词 双特异性蛋白磷酸酶6 促分裂原活化蛋白激酶 ERK 肿瘤 dual specificity protein phosphatase 6 mitogen-activated protein kinase ERK tumor
分类号 R730.2 [医药卫生—肿瘤]
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参考文献14

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临床与病理杂志
2014年 第2期

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