纳洛酮联合醒脑静治疗高血压性脑出血的临床疗效观察

Efficacy of naloxone combined with Xingnaojing injection in treatment of hypertensive cerebral hemorrhage

目的观察纳洛酮联用醒脑静治疗高血压性脑出血的临床疗效及对血肿的影响。方法根据随机数字表法将120例高血压性脑出血患者分为对照组、纳洛酮组、醒脑静组和联合治疗组,每组30例。对照组采用常规方法治疗,纳洛酮组、醒脑静组和联合治疗组在此基础上加用纳洛酮、醒脑静和两种药物联合治疗。观察并比较患者治疗前和治疗后第3、7、15和30天的血肿量、脑水肿指数、神经功能缺损评分。结果在治疗前和治疗后第3天,对照组、纳洛酮组、醒脑静组和联合治疗组间血肿量、脑水肿指数和神经功能缺损评分比较差异均无统计学意义(均P>0.05);在治疗后第7、15和30天,对照组、纳洛酮组、醒脑静组和联合治疗组间血肿量、脑水肿指数和神经功能缺损评分比较差异均有统计学意义(均P<0.05)。联合治疗组血肿量、脑水肿指数和神经功能缺损评分较纳洛酮组和醒脑静组显著低于对照组(均P<0.05)。结论纳洛酮联用醒脑静治疗高血压性脑出血可以更好地促进血肿吸收,减轻脑水肿,改善神经功能缺损。

Objective To assess the efficacy of naloxone combined with Xingnaojing injection in treatment of hypertensive cerebral hemorrhage. Methods One hundred and twenty patients with hypertensive cerebral hemorrhage admitted in hospital were randomly divided into control group, naloxone group, Xingnaojing group and combined treatment group with 30 cases in each. Patients in control group received conventional treatment, and patients in naloxone, xingnaojing, combined treatment groups received additional naloxone, Xingnaojing, naloxone with Xingnaojing treatment, respectively. The changes of hematoma volume, cerebral edema index and neurological function defect scores were compared before and after treatment. Results The differences of hematoma volume, cerebral edema index and neurological function defect score were not significant before and 3d after treatment among 4 groups （al P＆gt;0.05）;the significant differences were observed at d 7, 15 and 30 after treatment （al P＆lt;0.05）. Compared with naloxone and Xingnaojing groups, the hematoma volume, cerebral edema index and neurological function defect score in combined treatment group were improved more markedly than those in control group （al P＆lt;0.05）. Conclusion Combined administration of naloxone and Xingnaojing injection is more effective in absorbing hematoma, relieving brain edema and improving neurological function defect than single drug treatment in patients with hypertensive cerebral hemorrhage.