脑卒中后抑郁与孤啡肽及单胺类递质的相关性研究

Association of post-stroke depression with plasma concentrations of orphanin FQ and monoamine neurotransmitters

目的探讨脑卒中后抑郁(PSD)与孤啡肽(OFQ)及单胺类递质之间的相关性。方法将PSD患者102例作为研究组,同期躯体健康、无抑郁的体检者100例作为对照组,比较两者血OFQ及单胺递质含量。结果研究组汉密尔顿抑郁量表(HAMD)评分显著高于对照组(P<0.01),研究组血OFQ、去甲肾上腺素(NE)含量均高于对照组,血5-羟色胺(5-HT)含量显著低于对照组(均P<0.05)。研究组OFQ与卒中危险因素间无明显相关性(均P>0.05),与5-HT含量呈负相关(r=-0.613,P<0.05),与NE含量、HAMD评分及神经功能缺损(NIHSS)评分呈正相关(r=01712、0.871、0.443,均P<0.05)。结论 OFQ与5-HT、NE含量相关,NIHSS评分越高,OFQ含量越高。OFQ有可能通过影响脑内的单胺类神经递质,从而导致PSD症状的发生、发展。

Objective To explore the relationship between post- stroke depression and plasma concentrations of orphanin FQ and monoamine neurotransmitters（NE）. Methods One hundred and two patients with post- stroke depression（study group） and 100 healthy subjects without depression （control group） were included in the study. Hamilton Depression Scale （HAMD） was used to evaluate the depression status. The plasma concentrations of orphanin FQ and monoamine neurotransmitters were mea-sured. Results The scores of HAMD in study group were significantly higher than those in control group （P＆lt;0.01）;the plasma concentrations of OFQ and monoamine NE were significantly higher than those in control group （P＆lt;0.05）, the concentrations of 5- serotonin（5- HT） in study group were significantly lower than those in control group （P＆lt;0.05）. There was no significant relation-ship between OFQ and the risk factors of stroke. The OFQ concentration was positively correlated with NE concentration （r=0.712, P＆lt;0.05） and HAMD scores （r=0.871, P＆lt;0.05）, and negatively correlated with 5- HT levels in study group （r=- 0.613, P＆lt;0.05）. Conclusion Plasma OFQ levels are correlated with 5- HT and NE levels, as wel as with the severity of neurologic deficit （NIHSS score）, which indicates that OFQ may lead to the post- stroke depression by interfering with the monoamine neurotransmitters in the brain.