血清铁蛋白与2型糖尿病患者下肢外周动脉疾病的相关性

RELATIONSHIP BETWEEN SERUM FERRITIN AND PERIPHERAL ARTERIAL DISEASE IN TYPE 2 DIABETES MELLITUS

目的探讨2型糖尿病患者血清铁蛋白(serum ferritin,SF)与下肢外周动脉疾病(peripheral arterial disease,PAD)的相关性。方法 2型糖尿病患者76例,根据踝臂指数(ankle brachial index,ABI)将ABI≤0.9的患者分为PAD组40例,ABI>0.9的患者为对照组36例,分别测定2组患者的SF、糖化血红蛋白、空腹血糖、空腹胰岛素、低密度脂蛋白胆固醇、高敏C反应蛋白。结果 PAD组患者SF明显高于对照组(P<0.05),SF与糖尿病下肢血管病变具有相关性。结论 SF可作为2型糖尿病患者下肢PAD预测因子。

Objective To study the relationship between serum ferritin （SF） and peripheral arterial disease（PAD） in type 2 diabetes mellitus（T2DM）.Methods A total of 76 patients with T2DM,according to the ankle brachial index （ABI）,ABI ≤ 0.9 of the patients were divided into group PAD 40 cases,ABI ＞ 0.9 patients as a control group of 36 cases,The levels of SF,fasting blood glucose（FBG）,glycosylated hemoglobin （HbA1c）,fasting insulin （FINS）,lower density lipoprotein-cholesterol （LDL-C）,hypersensitive C-reactive protein （hsCRP） were measured.Results The SF level of PAD group was significantly higher than that of the control group （P ＜ 0.05）.The SF was positively correlated with PAD.Conclusion The SF can be used as a predictive factor of PAD in T2DM patients.