期刊文献+

B族维生素干预与脑卒中防治的相关性研究 被引量:2

下载PDF
导出
摘要 高同型半胱氨酸血症(hypohomocysteinemia,Hhcy)通过多种机制诱发动脉粥样硬化(atherosclerosis,AS),成为卒中防治领域的研究热点.理论上B族维生素干预可以降低血浆同型半胱氨酸(homocysteinemia,Hcy)水平,进而有效防治卒中.中美卒中防治指南均推荐使用多种B族维生素干预Hhcy.但多个大型临床研究结果显示,B族维生素干预治疗并未降低卒中的发生及再发风险.现就Hhcy的发生机制、Hhcy与卒中发病风险、B族维生素干预治疗后Hcy水平及卒中风险的相关研究综述如下.
作者 康慧 刘俊艳
出处 《河北医科大学学报》 CAS 2014年第4期483-486,共4页 Journal of Hebei Medical University
  • 相关文献

参考文献24

  • 1GOLDSTEIN LB,BUSHNELL CD,ADAMS RJ,et al.Guidelines for the primary prevention of stroke:a guideline for healthcare professionals from the American Heart Association/American Stroke Association[J].Stroke,2011,42 (2):5 l 7-584.
  • 2中国缺血性脑卒中和短暂性脑缺血发作二级预防指南2010[J].中华神经科杂志,2010,43(2):154-160. 被引量:954
  • 3TOOLE JF,MALINOW MR,CHAMBLESS LE,et al.Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke,myocardial infarction,and death:the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial[J].JAMA,2004,291 (5):565-575.
  • 4VITATOPS TRIAL STUDY GROUP.B vitamins in patients with recent transient ischemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial:a randomised,double-blind,parallel,placebo-controlled trial[J].Lancet Neurol,2010,9 (9):855-865.
  • 5KANG SS,WONG PW,MALINOW MR.Hyperhomocyst (e)inemia as a risk factor for occlusive vascular disease[J].Annu Rev Nutr,1992,12:279-298.
  • 6MCCULLY KS.Vascular pathology of homocysteinemia:implications for the pathgensis of arteriosclerosis[J].Am J Pathol,1969,56 (1):111-128.
  • 7UNAL E,MUNGAN S,BILEN S,et al.The effects of lipoprotein (a) and homocysteine on prognosis and risk factors in acute ischemic stroke[J].Int J Neurosci,2013,123(8):532-536.
  • 8HANKEY GJ.Is plasma homocysteine a modifiable risk factor for stroke?[J].Nat Clin Pract Neurol,2006,2 (1):26-33.
  • 9MARTIN-HERRERO F,MART(I)N-MOREIRAS J,PABON P,et al.Homocysteine and outcome in young patients with acute coronary syndromes[J].Int J Cardiol,2007,118 (2):183-188.
  • 10ARONOW WS,AHN C,GUTSTEIN H.Increased plasma homocysteine is an independent predictor of new atherothrimbtic brain infarction in older persons[J].Am J Cardio1,2000,86 (5):585-586.

二级参考文献7

共引文献962

同被引文献27

引证文献2

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部