三黄膏联合蜂蜜防治乳腺癌术后放射性皮炎的疗效观察

Efficacy Observation of Sanhuang Ointment Combined with Honey in the Treatment of Radio-dermatitis of Breast Cancer

目的:观察三黄膏联合蜂蜜防治乳腺癌术后放射性皮炎的临床疗效。方法:选择80例乳腺癌接受放射性治疗的患者,按数字表法随机分为试验组和对照组,每组40例。其中,试验组使用三黄膏联合蜂蜜进行放射野的局部涂覆,对照组使用硫酸镁软膏进行放射野的局部涂覆,比较两组患者治疗后5周出现的局部皮肤症状,出现轻度、中度及以上皮肤改变的时间以及放射性皮肤损伤分级情况。结果:试验组局部皮肤表现为水肿、瘙痒、脱屑及疼痛的比例均少于对照组,差异有统计学意义(P<0.05);试验组出现轻度、中度及以上皮肤改变的时间均慢于对照组,差异有统计学意义(P<0.05);试验组出现Ⅱ级及以下皮肤病变的比例多于对照组,Ⅲ级及以上级别皮肤病变的比例少于对照组,差异有统计学意义(P<0.05)。结论:三黄膏联合蜂蜜对乳腺癌术后放射性皮炎的防治有较好的疗效。

OBJECTIVE： To observe the clinical efficacy of Sanhuang ointment combined with honey in the treatment of radio- dermatitis of breast cancer. METHODS： 80 patients with radio-dermatitis of breast cancer were randomly divided into 2 groups with 40 cases in each group. Trial group was given Sanhuang ointment combined with honey for local use of radiation field; control group was given Magnesium sulfate ointment for local use of radiation field. The local skin symptoms, the time of mild to moder- ate skin changes and radioactive skin injury were compared between 2 groups 5 weeks after treatment. RESULTS： In trial group, the proportion of local skin edema, itching, desquamation and pain were all less than in control group; there was statistical signifi- cance （P〈0.05）. The time of mild to moderate skin change in trial group was longer than in control group; there was statistical sig- nificance（P〈0.05）. The proportion of grade Ⅲ skin lesion or below in trial group was higher than in control group, and that of grade IU skin lesion or above in trial group was lower than in control group; there was statistical significance（P〈0.05）. CONCLU- SIONS： Sanhuang ointment combined with honey have significant effect on radio-dermatitis of breast cancer.